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Objective: through observation research object plasma endogenous carbon monoxide concentration, explore the OSAS hypertension plasma carbon monoxide level changes of this special hypertensive populations. Methods: snoring and / or high blood pressure in patients with 186 cases from 2006 to 2007 in the Xinjiang Autonomous Region People's Hospital of hypertension outpatient visits and hospitalizations of sleep as the object of study, 24-hour ambulatory blood pressure monitoring and polysomnography (PSG OSAS and hypertension group of 120 patients, 36 cases of simple hypertension), OSAS and hypertension diagnostic criteria are divided into pure OSAS group 30 cases, separate the healthy control group (20 cases). Polysomnography using the Australia COmpumedics 44 PSG monitor. 24-hour ambulatory blood pressure monitoring: American Spacelabe90217 portable non-invasive ambulatory blood pressure monitor. Plasma CO level was measured according to the method reported by Chalmers. All of the subjects were excluded from severe anemia, polycythemia disease, the use of erythropoietin in patients; rule out serious heart, brain, kidney and liver disease: exclude thyroid dysfunction, diabetes, secondary hypertension patients. Results: 1) OSAS patients, regardless of whether the merger hypertension, abdominal circumference, neck circumference was significantly greater than the healthy control group; same time as the OSAS patients with AHI increased abdominal circumference, neck circumference is increased thickening; further correlation analysis AHI and body mass index, abdominal circumference, neck circumference was positively correlated. Oxygen saturation less than 90% of the time (TSAO 2 <90%) with age, body mass index, abdominal circumference were positively correlated. The lowest oxygen saturation (minSaO 2 ), with age, body mass index, abdominal circumference, neck circumference was negatively correlated. 2) with OSAS and hypertension groups and pure OSAS group plasma carbon monoxide levels were significantly higher than the healthy control group (p <0.05). The correlation analysis showed that the carbon monoxide level of AHI was positively correlated (r = 0.206, p = 0.029). OSAS, hypertension these two factors factorial analysis of interaction of AB P> 0.05, that there is no interaction, the main effects of the factors OSAS A P <0.05, OSAS on plasma carbon monoxide levels exist affect endogenous carbon monoxide levels can increased plasma carbon monoxide levels. The B factors hypertensive main effect P> 0.05, not statistically significant, we believe that the high blood pressure did not have an impact on plasma carbon monoxide levels. Stepwise multiple regression analysis, the lowest nocturnal oxygen saturation is variable OSAHS patients plasma carbon monoxide level was introduced in the regression equation. 3) moderate OSAS whether hypertension dDBP lower than light nDBP, severe OSAS (p <0.05), while moderate OSAS patients the plasma CO than light, in patients with severe OSAS, but no significant difference (p> 0.05) . Conclusions: 1) age, body mass index, neck circumference, abdominal circumference is closely related to the severity of OSAS patients, neck circumference, abdominal circumference than body mass index is better. 2) OSAS increased plasma carbon monoxide levels, hypoxemia cause OSAS patients CO synthesis increased. 3) endogenous carbon monoxide as a protective factor, may be involved in the formation of OSAS patients with hypertension.
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