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Effects of Benefiting-bone Capsule on Levels of 5-HT、5-HTT and 5-HTR2B Subunit in Bone Tissue of Ovariectomized Rats with Osteoporosis

Author: XiaJin
Tutor: ZhangRongHua
School: Jinan University
Course: Traditional Chinese Medicine
Keywords: Yi Gu Capsule Osteoporosis Bone tissue 5 - HT 5 - serotonin transporter 5 - HT 2B receptor
CLC: R285.5
Type: Master's thesis
Year: 2008
Downloads: 74
Quote: 1
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Abstract


Objective: To observe pure herbal compound Yigu Capsule on ovariectomized rat bone cells on the surface 5 - hydroxytryptamine (5-HT), 5 - serotonin transporter (5-HTT), 5 - HT 2B receptor (5 -HTR 2B ) expression, and to explore Yigu capsule treatment of osteoporosis (OP) in vivo effect may be part of the mechanism. Methods: 1.60 10-month-old female SD rats were randomly divided into model group and sham operation group, model group 48, the sham group 12. Model in ovariectomized rats 12 weeks method to copy model of osteoporosis; dual energy X-ray absorptiometry bone mineral density was measured to determine the successful model. (2) modeling at 12 weeks will determine the successful replication group rat model of osteoporosis and then randomly divided into model control group, low dose group Yigu capsule, the benefits of bone capsule dose group and high dose group Yigu capsule on benefits Bone Capsule low, medium and high dose group rats were given the equivalent dosage 1,3,9 times the adult clinical benefits of bone capsule liquid gavage 12 weeks of treatment, sham-operated group and model control group given saline. 3 using immunohistochemistry to detect the distal femur trabecular bone surface cells 5-HT ,5-HTT and 5-HTR 2B . 4 using SPSS11.5 statistical software, using rank sum test method level data were compared between groups. Results: In 12 weeks of modeling, model group and sham group, rats were multiple sites of bone tissue mineral density were significantly decreased (P <0.05). (2) modeling at 24 weeks to detect the rat bone cells on the surface 5-HTT expression, blank model group and sham group decreased significantly (P <0.05); Yi Gu Capsule low, medium and high dose group was significantly higher in the model control group (P <0.05); Yigu capsule, the high-dose group was significantly higher than the sham group and low dose group Yigu capsule (P <0.05); sham group and low dose group Yigu capsule, the benefits Bone capsules dose group and high dose group there was no significant difference (P> 0.05). 3 modeling at 24 weeks to detect the surface of cells in the bone tissue of rats 5-HTR 2B and 5-HT expression levels between the groups were not significantly different (P> 0.05). Conclusion: 1.10 old SD female rats ovariectomized 12 weeks successfully replicate the OP experimental animal models. 2 In ovariectomized rats during the formation of OP cells on the surface of bone tissue decreased levels of 5-HTT may play an important role. 3 dose-dependently increased bone cells on the surface 5-HTT may be beneficial bone in ovariectomized rats OP Treating one of the mechanisms.

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