|
The main research content in the three reaction conditions phenylthio the trimethylsilyl reagents ( PhSTMS , ) synthesis of asymmetric aryl sulfide : TBAF -assisted catalysis, catalytic TBAF -assisted microwave conditions and Cs 2 < / sub> CO 3 the auxiliary PhSTMS reagent synthesis of asymmetric aryl sulfide. Paper is divided into four chapters: the first chapter in the recent years , the synthesis of ether , thioether compound method are reviewed , including : Ullmann reaction , aromatics nucleophilic substitution reaction ( SNAr ) , transition metal-catalyzed reaction , these data experiment to carry out a theoretical basis . In the second chapter tetrabutylammonium fluoride ( TBAF ) catalysis, auxiliary PhSTMS reagents with halogenated , nitro aromatic compounds by the aromatics nucleophilic substitution reaction ( the SNAr reaction ) synthesis asymmetric aryl sulfide , this method of transition metal reagents catalyzed compared with the advantages of easy operation, high economic efficiency, excellent yield . In the third chapter chronicles The second chapter describes the general conditions based on the use of the microwave reactor , microwave conditions TBAF catalysis , auxiliary PhSTMS reagent synthesis of asymmetric aryl sulfide . Compared with the reaction under normal conditions , the former has a short reaction time, high yield advantages in the microwave conditions . In the fourth chapter discusses the Cs 2 CO 3 auxiliary PhSTMS of reagents with halo, nitro aromatic compounds to generate asymmetric aryl sulfide . The method has the advantages of simple , inexpensive raw materials , mild reaction conditions , environmental pollution and efficient .
|