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Study on Guanxin Cataplasm and Shexiangzhuanggu Cataplasm

Author: YuXuHong
Tutor: YangXiangLiang；LiuWei
School: Huazhong University of Science and Technology
Course: Polymer Chemistry and Physics
Keywords: Guanxin cataplasm Shexiangzhuangu cataplasm Prescription and preparation technique Quality study Determination Transdermal drug delivery
CLC: TQ461
Type: Master's thesis
Year: 2007
Downloads: 121
Quote: 1
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Abstract


Coronary heart disease （CHD） and Rheumatism endangers human’s health seriously. Guanxin plaster and Shexiangzhuanggu plaster is drug of curing CHD and Rheumatism, respectively. There are many shortcomings such as strong adhesion, skin irritation and low drug loading. In this paper, Guanxin cataplasm and Shexiangzhuanggu cataplasm were prepared with hydrophilic polymeric material. The contents of volatile compounds were determined by gas chromatography （GC）. The content of aconitine in Shexiangzhuanggu cataplasm was determined by high-performance liquid chromatography （HPLC）. Percutaneous ability of Shexiangzhuanggu cataplasm was investigated.The main results are as follows:（1） Guanxin cataplasm and Shexiangzhuanggu cataplasm were prepared. The adhesion, paste content and shaped characteristic were inspected according to 2005 Edition of Chinese Pharmacopoeia. The results indicated that the adhesion was moderate. The paste contents of the two cataplasms on 100 square centimeters were 8.325 g and 6.247 g, respectively. And shaped characteristic of the two cataplasms was excellent. Compared with plaster of Traditional Chinese Medicine （TCM）, cataplasm of TCM has the features of moderate adhesion, high drug loading, appropriate water vapor permeability and good skin compatibility.（2） The content of camphor, menthol in Guanxin cataplasm was determined by GC and camphor, menthol, borneol, methyl salicylate in Shexiangzhuanggu cataplasm were determined by GC, respectively. The GC system consists of temperature program, capillary column, PEG-20M as the stationary phase, nitrogen as the carrier gas, FID as the detector. Internal standard method was applied. The method is simple, having good precision, good stability and high recovery. The linear ranges of camphor, menthol, borneol, methyl salicylate are 53.24～479.16μg/mL （r=0.9998）,51.14～460.26μg/mL （r=0.9997）,50.28452.52μg/mL （r=0.9992）,49.42444.78μg/mL （r=0.9995）, respectively. （3） Shexiangzhuanggu cataplasm and Shexiangzhuanggu plaster were compared by percutaneous absorption experiment using vertical Franz diffusion cells. The results showed that the release profiles in vitro of methyl salicylate and camphor were in accordance with Higuchi equation. The relations between cumulative penetration content Q and t1/2 satisfied Higuchi equations, which were Q=0.4859t1/2+0.586 （r=0.9881）, Q=0.2734t1/2-0.2482 （r=0.9846）, respectively. Cumulative penetration content in 12 h was 0.722 mg/cm2 and 1.092 mg/cm2, respectively.（4） The content of toxic components-aconitine in Shexiangzhuanggu cataplasm was detected by HPLC （Hypersil ODS2 C18 column and UV-detector）. External standard method was applied. The mobile phase was methyl alcohol-0.05% triethylamine （70:30）. Aconitine linear range was 12.68126.80μg/mL. Detectability was 3 ng. Degree of precision was 0.69% （n=6）. Recovery rate of aconitine was 96.22% （RSD=1.62%）.

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