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The the white back thirty-seven (Gynura divaricata (L.) DC) Asteraceae thirty-seven, grass species, whichever folk blades for the treatment of diabetes, a preliminary study found containing mainly flavonoids, triterpenes, sterols, nucleoside compounds reported in the literature containing hepatotoxic pyrrolizidine alkaloids. This study, dialogue back notoginseng chemical composition of the extraction and separation, focusing on one of the alkaloids were detected by LC-MS ~ n, the monitoring of the seasonal variation of the total flavonoids of total flavonoids and cork ketone The hypoglycemic effect was evaluated with a view to the development and utilization of the white-backed notoginseng provide more scientific basis. The specific findings are as follows: 1. By silica gel column chromatography from the white-backed thirty-seven ground part of the isolated 10 compounds are recognized based on spectral data and physicochemical properties of n-eicosane (n-Eicosane 1), tetracosanol (Tetracosanol 2), twenty the eight-alkanoic acid (Octacosanoic acid 3), Octacosanol (Octacosyl alcohol 4) palmitic acid (Palmiticacid 5), stigmasterol-3-O-beta-D-pyran-glucosidase (stigmasterol-3-O-beta -D-glucopyranoside 6), stigmasterol (Stigmasterol 7), β-sitosterol (p-sitosterol 8) the carrots the glycoside (Daucosterol), friedelin (Friedelin 10). 2. Using liquid chromatography with multi-stage mass spectrometry (LC-MS ~ n), the white-backed detected in Notoginseng contains two different types of pyrrolizidine alkaloids (HPA), molecular weight of 335 and 365.3, respectively. Dialogue back Sanchi aerial part of the seasonal variation of the total flavonoids monitoring results show that, from April to May, total flavonoids lower to higher levels of total flavonoids in August. As an indicator of total flavonoid content, considering the meteorological factors that determine the white backed thirty-seven optimum harvest time in mid-August. 4. Animal experiments showed that the Panax notoginseng flavone white-backed no significant effect on blood sugar in normal mice, but can be significantly reduced due to streptozotocin diabetic mice, blood glucose levels and serum TC, TG content was significantly increased SOD activity, significantly elevated serum insulin levels; the friedelin can significantly reduce the streptozotocin-induced diabetic mice, blood glucose levels. Speculated that the Panax notoginseng flavonoids and friedelin of white-backed hypoglycemic mechanism may regulate blood lipids, improve antioxidant capacity, reduce free radical damage of pancreatic β-cells, repair damaged islet β-cells or promote islet beta cell regeneration, thus increased insulin secretion.
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