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In this paper, the maximum electric shock, pentylenetetrazol, strychnine and pilocarpine four groups epilepsy animal models of observed parameters Po Tang antiepileptic effect and its mechanism. The Experimental Results kneeling Ming: a. The parameter Po soup enhanced the largest electric shock, pentylenetetrazol and disabilities Ning attack threshold (CD50), can significantly improve pentylenetetrazol and strychnine half lethal dose (LD50) after compared with the control group, p < 0.05, p <0.01; a terror of pilocarpine-induced status epilepticus good effect. II. Pilocarpine model proved no effect on this side of the amino acid under non-pathological nervous system gingival level; attached convulsions state can inhibit glutamate levels rise, to promote the release of GABA; animals have convulsions. Although not to reduce the elevated levels of glutamate, but can increase the concentration of brain tissue of GABA. Measured by high performance liquid chromatography results are as follows: Chinese medicine control group brain ASP, Glu, GABA, Gly were 4.23 ± 1. 38,9.16 ± 3.0l, 2.55 ± 0.91,2.09 ± 0.64μmol · g ~ (-1) brain wet weight, blank control group is 3.61 ± 0.5l, 8.53 ± 0.79,2.04 ± 0.51,1.43 ± 0.23μmol · g ~ (-1) brain wet weight of the two groups for all comparisons p> 0.05; prevention Chinese medicine group (the Chinese medicine 4g/kg pre give pilocarpine treated rats made an induced status) Glu 9.07 ± 1.33μmol · g ~ (-1) brain wet weight, compared with the blank control group, no differences (p> 0 .05), GABA brain wet weight, compared with blank control group was significantly higher (150%, p <0.05) and 3.11 ± 0.62μmol · g (-1); treatment group (1l.29 ± 1. 80μmol · g (-1) wet weight) and brain model control group Glu (l2.67 ± 3.07μmol · g (-1) brain wet weight) than the control group (p |