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Purpose since Charnley recommended a low coefficient of friction total hip arthroplasty (THR) for more than 30 years of history, he has greatly promoted the development of joint surgery, to be so many joint ill newborn, pain reduction or disappearance of a significant improvement in joint function . With the aging of society, the 65-year-old aging population is increasing year by year, Europe and the United States line THA positive growth rate of 5% per year to testify further relaxation because of 30 years of successful experience in the surgery, even at high levels of activity young patients may also be applied to the implementation of the postoperative infection rate has dropped to less than 1%, prosthesis design, materials, process improvement, and has rarely prosthesis fracture. Implant materials in continuous improvement, prosthesis design and surgical techniques continues to progress, but still 15 to 20 percent of the total hip renovated renovated mostly cause loosening of the prosthesis. It is recognized that in recent years: the the artificial joints Forward loose addition to mechanical factors, mainly long-term wear and prosthesis or dissociation produced particles (debris) induced biological response (biologic reponse). Of aseptic loosening of the prosthesis (aseptic loosening) in the past 30 years, has been the main problem affecting arthroplasty life. Therefore, the biocompatibility of the artificial joint material debris (wear particles) is one of the important research topics in the field today. The large number of clinical researches have confirmed the presence of polyethylene wear debris generated by wear of the prosthesis and the metal particles, these particles with the prosthesis in the surrounding tissue in the loosening of artificial joint loosening related. However, the results of these studies and more based on different levels, the biological response of the debris of a variety of different sizes prosthesis material aggregate, failed prosthesis loosening induced biological effects of different materials, different sizes, different amount of debris make a comparative analysis, respectively. Made some exploration of the issues in this regard to provide a theoretical basis for the clinical use of a new prosthetic materials, improved surgical methods, as well as clinical exploration of a new viable prevention and treatment of the prosthesis forward loose, to extend the service life of artificial joints of the drug. Content and methods. Biocompatibility of different materials debris research and the debris of the same material, the size, the number of biological reactions. The different artificial joint material (UHMWPE, PMMA, CoCrMo alloy, TiAlV alloy of HA, PEEK) co-cultured in vitro with Ana-1 mice macrophage cell line, respectively spawned joint material debris biocompatibility research abstracts at 6,24,48,72 'J \\ when sampling, morphology and phagocytic macrophages (macroPhages) was observed in the light microscope, measuring the culture after 48 hours ILI. With i, TNFJ, Statistics biological response in a variety of materials whether there were significant differences in the comparative analysis of Mrp similarities and differences between in vivo and in vitro phagocytosis. The same amount will be different, different size of UHMWPE macrophage cell line in vitro and naJ mice co-cultured measured cultured for 48 hours after IL Diao, INFJ, to understand the relationship between the size of the wear debris, the number of biological reactions. 2, H-phosphate (Biphosphonates) and NSAIDS macrophage-mediated osteolysis (Osteolysis) Group A: UHM WP wind q and M. After 48 hours the supernatant added isotope '℃ a labeled mouse calvaria and BP measured skull absorption BP's ability to inhibit wear debris to stimulate the process of MRP-mediated osteolysis. Group B 100urn (magic stone 7 Guests 3.88; 167.50 ± 4.33) is 5 spawned joint material debris biocompatibility study summary difference between a highly significant o <0 knife 1 50 ~ 100urn group with learning 0Oum difference no statistically significant earners> 0 knife MQ release osteolytic factors increase with the increase of the amount of debris, differences between groups were significant (P <0 * 5). 10 '/ m and the group (** 7 Guests are .33;-6O * Sze 2.83) with the control group u5.83 soil 1.92; 41.67 ±
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