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The Glycyrrhiza chemical composition and antitumor activity of

Author: ShiRongHuo
Tutor: ZuoZuoMing
School: Nanjing University of Traditional Chinese Medicine
Course: Of Pharmacy
Keywords: Glycyrrhiza 21α-hydroxy-3-oxo-oleana-11, 13 18-diene-29-oic acid 10 - methoxy- US Di homopterocarpin 5α-stigmastan -3,6 - dione Betulinic acid Daucosterol After Mo homopterocarpin β- sitosterol 4 ', 7 - dimethoxy - isoflavone US - Di homopterocarpin Different light licorice phenol 9 - methoxy coumestrol The Mans propionate spend prime Macedonia acid The antitumor HepA tumor lines
CLC: R285.5
Type: Master's thesis
Year: 2001
Downloads: 335
Quote: 0
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Abstract


From legume licorice genus Glycyrrhiza (Glycyrrhiza pallidiflora Maxim) roots and rhizomes of separation of 17 compounds ( I to XVII ) , according to the physical and chemical properties and UV , IR , EIMS 1 < / sup> HNMR < sup> 13 CNMR and DEPT spectral data to determine the structure of the 13 compounds were : after Mok homopterocarpin , ( homopterocarpin III) the 5α - stigmast -3,6 - dione (5.α -Stigmastane-3 ,6-dione, Ⅴ), β- sitosterol ( beta -sitosterol , VI ), 4 ' , 7 - dimethoxy isoflavone (4' ,7-Dimethoxyisoflavone, Ⅶ), betulinic acid ( Betulinic acid, Ⅷ), U.S. Di homopterocarpin , ( Medicarpin IX) , different the light licorice phenol ( Isoglabrol XI) , 10 - methoxy U.S. Di homopterocarpin , (10 - methoxy- medicarpin XII) , 9 - methoxy Hong beans estrogen phenol (9 - Methoxycoumestrol Ⅹ Ⅲ ) , 21α - hydroxy - 3 - oxo - oleana - 11 , 13 ( 18 ) - diene - 29 - oic acid ( Ⅹ Ⅳ ) , Mans C spend hormone ( Formononetin , Ⅹ Ⅴ ) , Macedonia acid (macedonic acid Ⅹ Ⅵ), daucosterol (Daucosterol, Ⅹ Ⅶ). Ⅹ Ⅳ a new compound , the the V and Ⅻ for the first time in Glycyrrhiza share VIII Ⅹ Ⅶ isolated from this plant for the first time . HepA tumor strain of mice inoculated entities the after Mo homopterocarpin , U.S. Di homopterocarpin 7 monomer HepA solid tumor inhibition was observed 5 monomer strong activity ( inhibitory > 40 %) , its in-depth evaluation of the work being carried out .

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