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Analysis and Study of Non-UV Absorption Drugs Based on Charge Transfer Reaction

Author: YeLu
Tutor: DanWeiGuang
School: Zhejiang University of Technology
Course: Drug analysis
Keywords: Charge Transfer Reaction Spectrophotometry High Performance Liquid Chromatography Non - UV absorption of drugs
CLC: R917
Type: Master's thesis
Year: 2010
Downloads: 64
Quote: 0
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Abstract


The charge-transfer complex, referred to charge transfer complex, and refers to the relative rich molecules by electron - electron donor and an electron relative lack of molecules - via charge transfer complex formed between the electron acceptor. Generate a charge transfer complex spectral analysis, called on charge transfer spectroscopy. Charge Transfer spectroscopy in chemistry, biochemistry, medicine, and drug analysis have a wide range of applications, especially in the quantitative analysis of the drug. Drug quantitative analysis is the use of the charge transfer complex has the characteristics of a particular color and a maximum absorption peak electron donor (drugs) and electron acceptor to generate, create a charge transfer spectrophotometric determination of drug content. The charge transfer spectroscopy applications in pharmaceutical analysis is the research focus in recent years, focusing on applications in the analysis of quinolones, sulfonamides, amino acids, cephalosporin class as well as other drugs. This paper will charge transfer Determination of absorption of drugs applied to the non-UV spectrophotometry, and the establishment of a new class of drugs Determination. And charge transfer theory into the pre-column derivatization high-performance liquid chromatography, and established a new method for non-UV absorption of the drug content based on the charge transfer reaction by HPLC. The first part of this paper, an overview of a charge transfer complex concepts put forward a charge transfer complex formation of electron donor and electron acceptor classification, as well as the charge transfer complex application. The second to the fourth part, by the type of electron acceptor reagents, charge transfer reaction medium, to buffer the pH of the solution and its amount of charge transfer reaction temperature and time, and the amount of the electron acceptor reagent charge transfer reaction factors the inspection, the establishment of the charge transfer reaction-based high-performance liquid chromatography determination of agmatine sulfate content; charge transfer spectrophotometry and high performance liquid chromatography for the determination of the content of sisomicin sulfate based on charge transfer reaction and based on high performance liquid chromatographic method for the determination of the charge transfer reaction carbocisteine ??content. And measuring the composition of each complex, the complex is the molar absorption coefficient and the association constant, is formed on the charge transfer complex mechanism was discussed. The fifth part of the paper, a summary and outlook. Two methods is simple, accurate, reproducible, satisfactory results can be used to determine the non-UV absorption drug content of bulk drugs and formulations.

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CLC: > Medicine, health > Pharmacy > Drug analysis
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