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The Expression of STAT3 and hTERT in Retinoblastoma and Its Clinicopathologic Significance

Author: WangYuZuo
Tutor: ZhangZuo
School: Lanzhou University
Course: Pathology and pathophysiology
Keywords: Retinoblastoma Signal transducer and activator of transcription Human telomerase reverse transcriptase Optic nerve infiltration
CLC: R739.7
Type: Master's thesis
Year: 2010
Downloads: 35
Quote: 0
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Abstract


Objective To investigate STAT3 and hTERT expression in retinoblastoma and its clinical and pathological significance . The method of using the immunohistochemical methods to detect STAT3 and hTERT expression in paraffin-embedded specimens of 27 cases of retinoblastoma histological type and clinical stage and prognosis relationship . Results ( 1 ) 27 RB STAT3 protein and hTERT positive expression rate of 77.8% ( 21 / 27 ) and 70.3% (19 / 27 ) , respectively . (2) related to the degree of differentiation of positive expression of STAT3 protein and hTERT and RB ( χ2 = 4.571 , χ2 = 4.863 ; P lt; 0.05 ) . (3) The positive expression of STAT3 protein and hTERT with RB or without optic nerve invasion ( χ2 = 6.075 P = 0.014, χ2 = 5.684 , P = 0.017 ) related . ( 4 ) STAT3 -negative patients hTERT protein expression positive rate of 27.3 % , STAT3 patients with negative expression of hTERT protein negative rate was 72.7% . Spearman rank correlation analysis (5) , STAT3 protein and hTERT expression correlation ( r = 0.085 , P = 0.633 ) . The the conclusion 1.STAT3 and hTERT and RB differentiation type of optic nerve infiltration closely related . RB tissue expression of STAT3 and hTERT no significant correlation , but they jointly promote the co-expression of the invasion and metastasis of RB . 3 . Detection RB in the high expression of signal transducer and activator of transcription (STAT3 protein ) and human telomerase reverse transcriptase (hTERT) as reflected RB new marker of the degree of malignancy , and contribute to the screening transfer of high-risk cases . The STAT3 and hTERT is expected to become a new target molecules of RB clinical .

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