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Clinical Observation in the Patients with Asthma and Rhinitis Use the Way of Upper and Lower Airway Treatment.

Author: WangXiaoJun
Tutor: YuChangLi
School: North China Coal Medical
Course: Internal Medicine
Keywords: Bronchial asthma Allergic Rhinitis ICS LABA IC Induced sputum Nasal secretions
CLC: R765.21
Type: Master's thesis
Year: 2010
Downloads: 50
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Abstract


Objective To compare inhaled ICS' dissertation">ICS LABA combined the nasal spray IC with inhaled ICS LABA treatment of bronchial asthma with allergic rhinitis alone verify on airway rule is more conducive to the control of asthma with clinical symptoms of patients with allergic rhinitis. Select the method of treatment in the Affiliated Hospital of North China Coal Medical Department of Respiratory outpatient light, moderate persistent bronchial asthma with allergic rhinitis 62 patients were randomly divided into two groups, A group taken by mouth suction salmeterol and fluticasone propionate powder inhalation (trade name: Seretide Seretide, manufactured by GlaxoSmithKline) twice daily and smoke once every suck 50μg / 250μg budesonide nasal spraying nasal spray (trade name: Renault Colter Rhinocort, manufactured by AstraZeneca), every morning and evening on each side of the nostril spray press, each pressed 64 μg. B group were treated orally inhaled salmeterol and fluticasone propionate powder for inhalation (drugs with group A), every day, morning and evening smoke once every suck 50μg / 250μg. Lung function, serum TIgE, serum ECP and peripheral blood of the EOS% after 4 weeks of treatment, the two groups were compared before and after treatment, induced sputum EOS%, the nasal secretions smear EOS strength and ACQ questionnaire score, rhinitis symptom score changes. Also select North China Coal Medical College Hospital No acute and chronic respiratory diseases and allergic diseases healthy volunteers as the healthy control group (C) 30. Comparing lung function among the three groups A, B, C, serum the TIgE, serum ECP after 4 weeks of treatment, peripheral blood EOS induced sputum from the EOS% whether the differences; A and B between the two groups in nasal secretions smear EOS strength ACQ questionnaire score, rhinitis symptom score any difference. Results after 4 weeks of treatment, A, B two groups of patients with lung function (FEV1%, FEV1/FVC%, PEF%) in varying degrees to improve serum TIgE, serum ECP, induced sputum EOS% rhinitis symptom score ACQ questionnaire scores were significantly reduced, within-group comparisons, the difference was statistically significant (P lt; 0.05) before and after treatment. Patients in group A after treatment the nasal secretions smear EOS intensity significantly decreased compared with before treatment difference was statistically significant (P = lt; 0.05); the the nasal secretions smear EOS intensity B patients after treatment no significant decline with treatment before the difference was not statistically significant (P = gt; 0.05). Peripheral EOS% had no significant decline compared with before treatment, the difference was not statistically significant (P = gt; 0.05) in group A and B patients after treatment. A, B, C after treatment among the three groups in lung function (FEV1%, FEV1/FVC%, PEF%) compared to the difference was statistically significant (P lt; 0.05), further pairwise comparisons, group A and group B The difference was not statistically significant (P = gt; 0.05), group C, with A, B group any one group, the differences were statistically significant (P = lt; 0.05). After treatment among the three groups A, B, C serum TIgE, serum ECP comparison, the differences were statistically significant (P lt; 0.05), further pairwise comparisons, A group, B group, C group any two groups. The differences were statistically significant (P = lt; 0.05). EOS% and induced sputum EOS% compared to the differences were statistically significant (P lt; 0.05) in peripheral blood after treatment among the three groups A, B, C, further pairwise comparison, the A group and B group, the difference was not statistically significant (P = gt; 0.05). Group C and Group A, B group any one group, the differences were statistically significant (P = lt; 0.05). Rhinitis symptom score after treatment, groups A, B, ACQ scale score and nasal secretions smear EOS strength there are statistically significant differences (P = lt; 0.05). Conclusions smoked ICS LABA combined with nasal spray the IC than mere mouth suction ICS LABA more comprehensive suppression on airway eosinophil-mediated inflammatory reaction; smoked smoked ICS LABA combined with nasal spray IC alone ICS LABA can reduce asthma merge TIgE in the serum of patients with allergic rhinitis and the ECP level, while the mouth suction mouth suction effect of ICS LABA ICS LABA combined with nasal spray IC than alone more significant; smoked ICS LABA combined with nasal spray IC simple smoked ICS LABA can improve light to moderate persistent asthma lung function in patients with allergic rhinitis, and mouth suction ICS the the LABA United nasal spray IC with simple mouth suck ICS LABA improve mild to moderate persistent asthma merger allergic rhinitis lung function in patients with no significant difference; smoked ICS LABA combined nasal spray IC simple mouth suction ICS LABA can improve asthma with rhinitis symptoms of patients with allergic rhinitis and asthma symptoms, improve the effect of the combination was more pronounced; 5, smoked short-term low-dose ICS LABA with ICS LABA combined with nasal spray the IC not reduce bronchial asthma, allergic rhinitis in patients with peripheral blood EOS.

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CLC: > Medicine, health > Otorhinolaryngology > Rhinology,nasal disease > Nasal disease > Rhinitis
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