Dissertation > Excellent graduate degree dissertation topics show

The Therapy of Microalbuminuric Patients with Type 2 Diabetes Mellitus and Hypertension

Author: FuXin
Tutor: HuangZhenWen
School: Zhengzhou University
Course: Internal Medicine
Keywords: Levamlodipine Candesartan Imidapril Hypertension Microalbuminuria Type 2 diabetes mellitus
CLC: R587.1
Type: Master's thesis
Year: 2009
Downloads: 40
Quote: 1
Read: Download Dissertation

Abstract


Background of diabetes mellitus (DM) is associated with a range of cardiovascular disease, diabetes mellitus (DM), 3 to 4 times increase in the risk of cardiovascular disease, and acute cardiovascular events accounted for half of the deaths of all diabetic patients. Intensive treatment of diabetes, high blood sugar, hypertension and dyslipidemia has been shown to reduce the morbidity and mortality of cardiovascular disease. Globally, the prevalence of adult diabetes is increasing. According to WHO estimates, there were already diabetic patients with about 175 million, will reach 300 million by 2025. U.S. National Health and Nutrition Examination Survey (NHANES) 1988-1994 diabetes prevalence was 5.1% and 6.5% in 1999-2002, to 7.8% in 2003-2006; diabetic population in China to type 2 diabetes mainly accounted for 93.7% of the diabetes. Diabetic patients, up to 70% incidence of hypertension, especially in elderly patients and male patients. The absolute benefit in populations with diabetes, hypertension, cardiovascular and renal complications, 35% to 45% and reduce high blood pressure than in the non-diabetic population in the greater. Diabetes and hypertension can be induced by chronic kidney disease, the two together to accelerate kidney damage. Urine microalbumin is kidney damage early markers of diabetic nephropathy urinary microalbumin hypertensive renal damage, there may be the same urine microalbumin. Therefore, this study examines the impact of the three-drug combination treatment of type 2 diabetes in patients with hypertension urinary microalbumin. Objective To investigate the calcium antagonist the (levamlodipine), angiotensin-converting enzyme inhibitors (ACEI) (imidapril) and angiotensin receptor blocker (ARB) (candesartan) combination regimens of 2 diabetic patients with hypertension trace protein in urine. Method hypertensive type 2 diabetes with urine trace protein was outpatient or inpatient 160 cases were randomly divided into four groups according to treatment sequence: (4mg) levamlodipine candesartan (2.5 mg, n = 40), Hom the candesartan (4mg) microphone stage Ⅰ (5 mg, n = 40), imidapril (5mg) levamlodipine (2.5mg, n = 40) and L-amlodipine besylate (2.5mg) candesartan sand The Tanzania (4mg) Imidapril treatment (5mg, n = 40), treatment for 3 months. Observe the changes in blood pressure, urine albumin before and after treatment. Results significantly lower blood pressure than before treatment (p <0.05), but among the four groups after the treatment of blood pressure, the difference was not significant statistically; urinary microalbumin albumin (UMALB) groups than before treatment to reduce (p <0.01) 3-drug combination therapy group decreased more significantly than two kinds of drugs combined therapy group: candesartan levamlodipine group before treatment (40.5 ± 9.6) mg / L than after treatment (25.2 ± 6.2) mg / L; group before treatment (41.3 ± 10.8) mg / L ratios after treatment (20.2 ± 6.3) mg / L; the imidapril group of levamlodipine, before treatment (43.3 ± 10.4) mg candesartan imidapril / L ratio after treatment (20.6 ± 6.4) mg / L; L-amlodipine candesartan cilexetil imidapril joint group before treatment (41.7 ± 10.2) mg / L ratios after treatment (15.6 ± 6.3) mg / L ; p <0.05. Conclusion Low dose candesartan imidapril levamlodipine, combined with effective blood pressure can improve early renal damage in type 2 diabetes patients with hypertension, and suggesting early renal damage as soon as possible joint antihypertensive therapy.

Related Dissertations

  1. Relationship between Level of Serum Uric Acid and Lower Extremity Arterial Disease in Patients with Type 2 Diabetes Mellitus,R587.1
  2. Efficacy and Safety of Biphasic Insulin Aspart 30 Once-daily Treatment in Patients with Type 2 Diabetes,R587.1
  3. The Blood Glucose Control and Influencing Factors in Type 2 Diabetic Patients with Oral Hypoglycemic Agents,R587.1
  4. Carotid Artery Wall Elasticity and Carotid Atherosclerosis in Diabetes Mellitus Patients with Microalbuminuria Using Ultrasonographic Elastography and High-freguency Ultrasound,R445.1
  5. Study on Knowledge, Attitude, and Behavior to Calcium Nutrition Among Patients with Hypertension in a Community,R473.2
  6. Effects of High-salt Dieet on Blood Pressure and the Remodeling of Carotid Arteries and the Intervention of Telmisartan in Wistar Rats,R544.1
  7. The Effects of Telmisartan on Essential Hypertension with Paroxysmal Atrial Fibrillation,R541.75
  8. Effect of Different Emotion Regulation Modes on Activities of Autonomic Nervous System of Essential Hypertensive Patients with Type A Personality under Emotion Stimulis,R544.1
  9. Association of Genetic Variation of UTS2 Gene with Type2 Diabetes Mellitus and Hypertension,R587.1
  10. Effect of Gastric Bypass on the Blood Glucose Level in Type 2 Diabetes Rat Model,R587.1
  11. Relationship between Postprandial Blood Pressure and Lower Extremity Arterial Disease in Patients with Type 2 Diabetes Mellitus,R587.1
  12. PSE lamivudine hepatitis B cirrhosis and portal hypertension clinical observation,R575.2
  13. The Comparison of Therapeutic Effect and Security between CSⅡ and MDI in Type 2 Diabetes Mellitus,R587.1
  14. The Characteristics of Coronary Angiography in Type 2 Diabetes Mellitus Patients with Suspected Coronary Artery Disease,R587.1
  15. Effect of Whey Protein on Improving Insulin Resistance and the Underlying Mechanisms,R587.1
  16. The Changes of T Lymphocyte Subsets and Costimulatory Molecules Before and After Shuxuetong Treatment in Type 2 Diabetes Subjects with Diabetic Kidney Disease,R692
  17. 50 Cases of Type 2 Diabetic Patients Serum Trace Element and Vitamin Change Analysis,R587.1
  18. Correlation Studies of Plasma Fatty Acids and Type 2 Diabetes Mellitus: Case Control Study,R587.1
  19. The Role of SIK1 in Type 2 Diabetic Nephropathy with Hypertension,R544.1
  20. A Retrospective Epidemiology Study of Comorbidities in Patients with Psoriasis,R758.63
  21. Effect of Candesartan on Expression of VEGF and MCP-1 in Rat Retina with Diabetetes Mellitus,R774.1

CLC: > Medicine, health > Internal Medicine > Endocrine diseases and metabolic diseases > Islet disease > Diabetes
© 2012 www.DissertationTopic.Net  Mobile