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Studies on Chemical Conconstitutents of Petroleum Extract from Kangaisan

Author: YiHui
Tutor: LouYiCeng
School: Wuhan University of Technology
Course: Pharmacy
Keywords: Anticancer scattered Material basis Petroleum ether GC Fingerprint Anticancer activity
CLC: R284
Type: Master's thesis
Year: 2010
Downloads: 38
Quote: 0
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Abstract


The anticancer scattered experience side of traditional Chinese medicine , good anti-tumor effect through clinical application , clinical commonly used in the treatment of lung cancer , liver cancer , brain cancer, and efficacy . The party used the herbs are commonly used non-toxic natural plant , Polygonum orientale bulk herbs for anti-cancer , the papers of the bulk material basis for the anti-cancer research . This thesis, under the guidance of Chinese medicine theory , through multidisciplinary research methods , the compound anticancer scattered as a whole , with the solvent method is divided into different polarity site . The pharmacological studies show that petroleum ether component separating portion of a good anti -tumor effect at high doses , anticancer bulk dried whole plant of the petroleum ether extract , by the use of silica gel , dextran gel ( Sephadex LH -20 ) column chromatographic methods such as separation and purification by physicochemical properties and spectral data to determine the structure of the compound ingredients isolated from the anticancer scattered in petroleum ether β-sitosterol alcohol ( I ) bears fruit acids ( II ) , 4,4 ' 8,8 '- tetrahydroxy - 3,3' - dimethoxy - diphenyl bis tetrahydrofuran ( III) , the cholesteric ethyl carbonate ( CHOLESTERYL ethyl carbonate) (TV) , cholesteric hydrogenated cinnamic acid ester ( V ), which compound cholesteryl ethyl carbonate (Ⅳ), cholesteryl hydrocinnamic ester ( V ) in the compound for the first time found that this pair of anticancer bulk of the material basis of great significance . GC-MS analysis of petroleum ether fraction of anticancer bulk chemical composition analysis , 20 compounds were identified , for the first time established anticancer bulk petroleum ether fraction fingerprint , calibrate the 20 common peaks the method has high sensitivity , good reproducibility , reliability ; and established fingerprint determination method , the analysis showed that the small differences between the anticancer scattered . Thus , the quality control of the anticancer scattered plants provides a reliable method of evaluation .

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CLC: > Medicine, health > Chinese Medicine > Of Pharmacy > Traditional Chinese medicine chemical
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