Dissertation > Excellent graduate degree dissertation topics show

Effect of Moxibustion on the GC Signal Pathway in Synoviocyte of Experimental RA

Author: WeiNing
Tutor: LiuXuGuang
School: Chengdu University of Traditional Chinese Medicine
Course: Acupuncture and Massage
Keywords: Moxibustion Rheumatoid arthritis Synovial cells Gene chip Glucocorticoid signaling pathway
CLC: R245
Type: Master's thesis
Year: 2010
Downloads: 47
Quote: 0
Read: Download Dissertation

Abstract


Objective: based on conclusive evidence of RA rabbit anti-inflammatory effects of moxibustion on experimental observation of moxibustion of experimental RA rabbit synovial cells glucocorticoid hormone ( GC ) signaling pathway , revealing moxibustion treatment of experimental RA anti- inflammatory effect of molecular signaling mechanisms . Methods: 36 Japanese white rabbits , weight, gender stratified randomly divided into control group ( blank control group ) , the RA model group ( model group ) and moxibustion treatment group ( treatment group) (n = 12) hungry animals. Average injection of Freund's complete adjuvant ( FCA ) on 0.5ml/kg bw model group and treatment group animals double rear knee joint cavity , blank group animals using the same method of injection volume of sterile saline as a control . Boyz moxibustion bilateral \Blank group and the model group was fixed , but not moxibustion therapy . Modeling before and after treatment days 3,6,9,12,15,18,21 were measured with a soft tape around each rabbit knee circumference. The rabbits were sacrificed 21 days after treatment , knee synovial tissue , the use of gene chips and bioinformatics analysis to detect , analyze synovial cells glucocorticoid ( GC ) signaling pathway 36 signal molecule expression . Results: modeling , rabbits left , right after the circumference of the knee was no significant difference ( P gt ; 0.05 ) ; each time point after modeling, model group left , right knee circumference was significantly higher than those in the normal group ( P lt ; 0.01 ) , persistent inflammation model : treatment the moxibustion group left , right knee circumference decreased compared with the model group ( P lt ; 0.05 ) , anti - inflammatory swelling prompt moxibustion . Model group and blank group , GC signaling pathways abnormally activated , a large number of pro-inflammatory signaling molecules upregulated ; compare the treatment group and the model group , the GC pathway partially inhibited inflammation -related signaling molecules were up-regulated , some of the signaling molecules There was no significant up or down ( not statistically significant ) , but the signaling molecules associated with anti-inflammation upward trend downward trend associated with pro-inflammatory signaling molecules . Conclusion: moxibustion has anti-inflammatory swelling effect , the regulation of moxibustion on experimental RA synovial cells of glucocorticoid hormones ( GC ) signaling pathway may play an important mechanism of the anti-inflammatory effects .

Related Dissertations

  1. Blockage type of rheumatoid arthritis clinical research for Zhou Naiyu academic thinking and clinical experience and Bi Yu Kang I,Treatment of late alpine,R259
  2. Detection Classical Swine Fever Virus and Porcine Circovirus Type 2 of Microarray Technique,S858.28
  3. The Expression and Clinical Significance of TH17 Cells Related Cytokines in the Patients with Rheumatoid Arthritis,R593.22
  4. Patients with rheumatoid arthritis serum soluble synergistic signaling molecules sPD-1, sPD-L1 and significance of measurement of the concentration,R593.22
  5. Expression and Clinic Significance of PD-1/PD-L1 Costimulatory Molecules in Peripheral Blood of Rheumatoid Arthritis,R593.22
  6. The Expression and Significance of Serum MIP-1β and MCP-1in Patients with Rheumatoid Athritis,R593.22
  7. Microarray Based Analysis of the Mechanism on Cardiovascular Drug Inducing Myocardial Injury,R96
  8. Experimental Studies on the Change of Circadian Rhythm and Gene Expression in Lung of Ventilation-induced Lung Injury in Rat,R563.8
  9. Comparative Studies of DNA Microarray and Sequencing in Genetic Diagnosis on the Patients with Enlarged Vestibular Aqueduct Syndrome,R764
  10. Distribution of Human Papillomavirus Type in Yao Ethnic Minority Group in Northern Guangdong,R737.33
  11. Association of the MDR1 3435 Polymorphism in Patients with Refractory Rheumatoid Arthritis in a Chinese Han Population,R593.22
  12. Diagnostic Value of Ultrasound for Imaging of MCP, PIP and Wrist Joints in Rheumatoid Arthritis-a Comparative Study with Magnetic Resonance Imagin,R593.22
  13. The Association between Androgen Deficiency, Obesity and Lipid Metabolism Genes in Males,R589.2
  14. Synovial Lesions in Ultrasound Evaluation of Rheumatoid Arthritis,R593.22
  15. Effects of MGF-Ct24E and Mechanical Stress on the Gene Expressing of Osteoblasts by Microarray Analysis,R329
  16. Exploration of Extraction, Purification Technique and Anti-rheumatoid Arthritis Activity of Total Saponins from Radix Clematidis Henryi,R285
  17. The study of the mechanism of action of Guizhi Fuzi Decoction rheumatoid arthritis in rats,R285
  18. Professor Qu Shuqin application dampness treatment of rheumatoid arthritis Experience,R249
  19. Warming needle moxibustion combined with traditional Chinese therapeutic mud Shop Du mandatory spondylitis clinical research,R259
  20. The Research of the Influence of Du-Moxibustion Across Ginger and Garlic to ESR and CRP in Treating as with Cold-damp Blocking Syndrome,R246
  21. Clinical Study of the Solid Shoulder Complement Element Acupuncture and Rehabilitation Therapy on the Treatment of Hemiplegic Shoulder Pain,R246

CLC: > Medicine, health > Chinese Medicine > Chinese medicine clinic > Acupuncture, acupuncture therapy
© 2012 www.DissertationTopic.Net  Mobile