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China is the world's worst affected countries endanger hypertension, according to the 2002 National Nutrition and Health Survey estimated prevalence at over 160 million, long-term high blood pressure can cause small artery atherosclerotic changes, affecting the heart, brain , kidney and other vital organ function and appearance-related complications, and ultimately can lead to organ failure and these effects lead to hypertensive crisis and other emergency. The face of such a high incidence of hypertension and severe complications of hypertension control rate is very low, it is possible to control blood pressure in the normal range in patients accounted for only 6.1%. In the past, people often use medicine to treat hypertension. Western medicine treatment of hypertension, often promising to achieve target blood pressure and frequent dosing subtraction, etc., therefore, often large fluctuations in blood pressure or blood pressure rebound phenomenon, in addition to Western medicine treatment of hypertension often cause headaches, dizziness, stretching, insomnia, irritability and other adverse reactions, a number of factors that make difficult to resolve the majority of hypertensive patients insist on taking the medicine, and the sights of traditional Chinese medicine. Chinese medicine is based on differentiation, emphasizing the overall treatment, symptom improvement is ideal. For example, when patients with hypertension, headache, dizziness, stretching, insomnia, irritability and other symptoms, Chinese medicine is due to liver and kidney, yin, yang hyperactivity of the wind due. Through heat purging fire, Pingganxifeng treatment, often in blood pressure at the same time, the symptoms also will be improved. The combined kidney of the law, with traditional Chinese medicine Liuweidihuangwan, beads and other wind calmed down after the treatment of liver or kidney, and even improve the quality of life, reduce nocturia and improve kidney function. To explore the mixture of Chinese and Western treatment of high blood pressure Po 00 normotensive and hypertensive patients with grade Ⅰ efficacy, the authors carried out the study. The study used a randomized, controlled, blinded clinical trial research methods, the traditional medicine nifedipine crowd as control, analysis of Chinese medicine treatment of high blood pressure Po 00 normotensive and hypertensive patients with grade Ⅰ changes in blood pressure after trends and the impact of TCM syndrome patients, but also analyzed the drug medication adherence and side effects, etc., in order for the clinical use of antihypertensive therapy Po 00 high grade Ⅰ normotensive and hypertensive populations provide a scientific basis, while The findings also the clinical treatment of hypertension Ⅱ and Ⅲ groups have an important reference. Methods June 2005 to September, to Henan Academy of TCM treatment of hypertensive patients meet the conditions of 630 cases (146 cases in which high-normal blood pressure, hypertension grade Ⅰ population 484 cases) as the research object. Prepared using STATA9.0 software program will completely randomized study 630 cases were randomly divided into A, B groups (high-normal blood pressure groups: A group of 72 cases, B group, 74 cases; hypertension grade Ⅰ crowd: A group of 235 cases , B group 249 cases). A group of subjects issuing buck Po 00, 2 times a day, 30mg / times; B group of subjects issuing traditional antihypertensive drug nifedipine, 2 times a day, 20mg / times, both drugs during the observation period are long-term use. Before treatment, the study collected basic demographic characteristics, factors that affect blood pressure points, TCM syndrome score and measure the patient's blood pressure; in taking the first two weeks, four weeks, six weeks, eight weeks, 10 weeks and 12 weeks, repeated Measuring blood pressure in the study and collect their symptom score; follow the end of the record and the remaining amount of drug adverse events and other information. Throughout the experiment using three blind approach, the study of observer and object of study groups do not understand the situation, but is responsible for data collection and analysis personnel do not understand the grouping, thus effectively reducing information bias. Different time points systolic, diastolic, TCM Hou points compared using repeated measures analysis of variance; treatment before and after treatment, the rate of cardiac dysfunction compared using x 2 test; red blood cell count before and after treatment , white blood cell count, hemoglobin count, total cholesterol and other biochemical markers were compared using paired t-designed two-sample comparison test. Using SPSS12.0 statistical analysis, test level is 0.05. The results of the high-normal blood pressure groups (1) The primary efficacy endpoint at different time points systolic and diastolic blood pressure were statistically significant differences in the average level, while different groups showed no significant difference between the systolic blood pressure: F group = 0.017, P> 0.05; F time = 47.442, P <0.001; diastolic F group = 0.001, P> 0.05; F Time = 59.25, P <0.001. (2) Secondary efficacy variables between different groups of TCM syndrome score difference was not statistically significant, F group = 0.259, P> 0.05; rather different time symptom score was statistically significance, F time = 26.747, P <0.001. (3) ECG monitoring cardiac function and biochemical parameters between two groups before treatment (x 2 = 2.560, P> 0.05) and after treatment (x 2 = 1.317, P> 0.05 ) showed no significant difference; total cholesterol before and after treatment (t = 0.912, P> 0.05), triglycerides (t = 0.499, P> 0.05), high density lipoprotein cholesterol (t = 0.439, P> 0.05) difference was not statistically significant. (4) Security Analysis Indicators red blood cell count before and after treatment (t = 0.171, P> 0.05), white blood cell count (t = 0.260, P> 0.05), hemoglobin count (t = 0.260, P> 0.05) difference was not statistically significant. 2 hypertension grade Ⅰ crowd (1) The primary efficacy endpoint at different time points systolic and diastolic blood pressure were statistically significant differences in the average level, while different groups showed no significant difference between the systolic blood pressure: F group = 0.068, P> 0.05; F time = 233.608, P <0.001, diastolic: F group = 8.400, P> 0.05; F Time = 282.80, P <0.001. (2) Secondary efficacy variables at different time points after administration of TCM Hou points difference was statistically significant, F time = 192.422, P <0.001, different groups of TCM syndrome score difference was not statistically significance, F group = 0.183, P> 0.05. (3) ECG monitoring and biochemical parameters between two groups before treatment (x 2 = 0.478, P> 0.05) and after treatment (x 2 = 2.986, P> 0.05) Heart dysfunction rate showed no significant difference; total cholesterol before and after treatment (t = 0.521, P> 0.05), triglycerides (t = 0.198, P> 0.05) high-density lipoprotein cholesterol (t = 1.106, P> 0.05) difference not statistically significant. (4) Security Analysis Indicators red blood cell count before and after treatment (t = 0.628, P> 0.05), white blood cells (t = 0.259, P> 0.05), hemoglobin (t = 0.897, P> 0.05) unchanged. Conclusion Whether for high normotensive or hypertensive populations grade Ⅰ, 00 were able to buck treasure continued, slowly lowering blood pressure, and its effect is not worse than the conventional drugs, in addition, antihypertensive drug side effects Treasure No. 00, low incidence of adverse events, patient medication compliance, coupled with its cheap, in certain clinical applications.
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