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Objective: To investigate the relationship between hypertension and obstructive sleep apnea syndrome (OSAS) is suspended , and its mechanism , to provide some reference for this particular type of hypertension clinical treatment . Methods: ① selected 41 hypertensive patients , synchronous 24 - hour ambulatory blood pressure (ABPM) and polysomnography monitoring ( PSG ) , combined with the OSAS those 21 cases for the experimental group (HT OSAS group ) , and non- OSAS pure high blood pressure , 20 patients of the control group (HT group ) , the next day of the experiment fasting detect red blood cell count ( RBC ) , hemoglobin (HGB), mean corpuscular hematocrit (HCG), blood sugar , cholesterol (TC), triglyceride (TG ). ② two groups of conventional low-salt diet , oral enalapril and / or nitrendipine two weeks of treatment , 24 - hour ambulatory blood pressure before and after treatment . ③ HT OSAS group antihypertensive effect in 14 cases, while receiving positive airway pressure (CPAP) treatment for 2 weeks , and to observe the changes in blood pressure . Results: ① age, height , weight , body mass index ( BMI ) , RBC , fasting glucose , TC mean daytime systolic blood pressure ( DSBP ) , daytime average diastolic blood pressure ( DDBP ) , average diastolic blood pressure at night (NDBP) between the two groups had no significant differences ( P gt; 0.05 ) the HGB, HCG , TG and night average systolic blood pressure (NSBP) HT OSAS group was significantly higher than the HT group , the difference was significant ( P lt; 0.05 ) ; ( 2 ) drug antihypertensive treatment after 2 weeks HT group, blood pressure compared with HT OSAS group was significantly decreased ( P lt ; 0.05 ) , no obvious change ( P gt HT OSAS group drugs before and after treatment ; 0.05 ) ; poor ③ The 14 cases of simple drug treatment efficacy of HT with OSAS patients at the same time accept CPAP therapy two weeks . , blood pressure decreased significantly . Conclusion : OSAS is one of the causes of hypertension , OSAS - related hypertension refractory , simple drug treatment did not show a good antihypertensive effect of CPAP therapy helps the recovery of such patients blood pressure .
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