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Wenyanghuoxue drug Ng Enhancement Effect of anti-cancer drugs to the tumor cells

Author: ShenLiLi
Tutor: LiZhong
School: Beijing University of Traditional Chinese Medicine
Course: Integrative Oncology
Keywords: Chemosensitivity Cinnamaledehyde MTT assay A549
CLC: R273
Type: Master's thesis
Year: 2005
Downloads: 145
Quote: 0
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Abstract


How to increase the sensitivity to chemotherapy in cancer cells is the key for decreasing the dose of chemotherapy, reducing toxic side effects and increasing effects. Chemosensitizer is one of the most important research on chemotherapy. Contemporarily, some chemosensitizers can’t expand the clinic application because of the toxic side effects. Clinical practices have improved that Chinese medicine can definitely improve the effect of chemotherapy and reduce adverse effct. There have been many research results which were reported of country.Since the pathogenesis of vicious tumor in clinic is of lack of Yangqi and of cold accumulation, and chemotherapy can enhance the lack of Yangqi, we think "cold accumulation" is the most important factor to influence the effect of chemotherapy and supplementing yang is regarded as the main theory of chemotherapy. So we chose Cinnamaledehyde as object of study. As the same time, we chose Tetramethylpyrazinein activating blood to combinate Cinnamaledehyde. We observed the antitumor cytotoxicity and the chemosensitivity of A549 cells to CDDP of Cinnamaledehyde, Tetramethylpyrazinein and Cinnamaledehyde plus Tetramethylpyrazinein, by MTT assay in vitro. This was the first time to report that Cinnamaledehyde was capable of enhancing the sensitivity of human lung adenocarcinoma cell A549 to Cisplatin. The cytotoxic effects of CDDP plus 20ug/ml, 13ug/ml CA were statistically significantly more cytotoxic than Cdd?(p<0.01) . The cytotoxic effects of CDDP plus 6.5ug/ml CA were not statistically significantly more cytotoxic than CDDP(p>0.05). The cytotoxic effects of 4ug/mlCDDP plus 200ug/ml TMP were statistically significantly more cytotoxic than 4ug/mlCDDP(P<0.01) . The cytotoxic effects of 4ug/mlCDDP plus 13ug/ml CA plus 100ug/ml TMP were statistically significantly more cytotoxic than 4ug/mlCDDP(p<0.01) , but the main chemosensitivity was the effect of CA . It suggested the possibility of " supplementing yang " to enhance the chemotherapeutic sensitivity of cancer cells. We will research the chemosensitivity of CA plus TMP go step further because of the limitation of this experiment.

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