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Objective: malignant lymphoma (Maligant Lymphoma) is one of the most common malignant tumor of childhood , the incidence has increased year by year trend . With further research and treatment , and constantly improve its response rate and disease-free survival rate has been greatly improved , but there is still a strong chemotherapy drugs side effects , such as multi - drug resistant variety . Its etiology , pathogenesis has not been fully elucidated , need to be further explored , whom the search for more effective treatment measures . Since it was discovered that the endothelial vascular factor is nitric oxide (NO) , the NO studies have mushroomed to become one of the hot spots of the contemporary medical research . In recent years, studies have shown that NO is closely related with the tumor , multiple processes involved in cancer development , prognosis , tumor prevention and transfer of new research areas . NO by nitric oxide synthase (NOS) the catalytic substrate L- arginine (L-arginine, L-arg) is generated , especially inducible NOS (iNOS) and tumor more closely . A variety of tumors , such as colon cancer , breast cancer , lung cancer, and so found the expression of iNOS , but the role of NO in pediatric malignant lymphoma and lymphoma cells and abroad rarely reported . This article by immunohistochemical technique the observed iNOS and vascular endothelial growth factor (VEGF) expression in pediatric malignant lymphoma biopsy specimens and its relationship with microvascular density (MVD) ; Youyi iNOSmRNA positive Burkitt's lymphoma cell line BJAB the cells for the study , the observed NO concentration changes of lymphoma cell growth , and thus the analysis of NO and iNOS in pediatric malignant lymphoma occurred , the role played in the development . To provide experimental evidence for NO preparations to participate in combination with chemotherapy for pediatric malignant
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