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Protective Effects of Astragaloside Ⅳ on Cerebral Ischemia/reperfusion Injury and Expression of APE-Ref-1 in Rats

Author: ZuoJingJing
Tutor: LiuYanXia
School: Tianjin Medical University
Course: Pharmacology
Keywords: Astragaloside Ⅳ Cerebral ischemia-reperfusion injury Radical No purine / pyrimidine nucleus without endonuclease / redox factor 1
CLC: R285
Type: Master's thesis
Year: 2005
Downloads: 114
Quote: 0
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Abstract


Ischemic cerebrovascular disease (ischemic cerebral vascular diseases, ICVD) is the result of human movement , language and cognitive abilities lost the primary disease , mortality is higher . Now commonly used in clinical thrombolytic treatment, although you can make ischemic cerebrovascular recanalization , while filling in brain tissue during reperfusion dysfunction and structural damage further. Cerebral ischemia-reperfusion injury of the pathophysiological mechanisms and to find effective prevention drugs and explore the possible role of drugs targets abroad has become a research hotspot . Cerebral ischemia-reperfusion injury and OFR (oxygen free radical, OFR) related to the role , effective anti- drugs may OFR prevention of cerebral ischemia-reperfusion injury . Astragalus has a long history of stroke treatment with astragalus resist the OFR effects. Astragalus reactive monomer astragaloside is good OFR scavenger , astragalus may play a role in one of the active ingredients . In astragaloside in astragaloside Ⅳ (astragaloside Ⅳ, AST) highest content , good water solubility , strong activity is expected to develop for the prevention and treatment of cerebral ischemia-reperfusion injury of new drugs effective parts . Healthy male Wistar rats were randomly divided into four groups , sham operation group , model group, high-and low -dose treatment group, high and low dose group animals 30min before ischemia were injected intraperitoneally AST 4mg/kg, 1 mg / kg sham group and model group were intraperitoneally injected with the drug equal volume of saline , with reversible middle cerebral artery occlusion intraluminal 1h 6h after reperfusion ischemia model in rats observed behavior of each group AST activities, with TTC and HE staining , quantitative and qualitative determination of brain tissue necrosis . Experiments show that the model group rats neurological deficit symptoms, mainly for mentioning tail floating, vessel occlusion of the contralateral side of the shoulder internal rotation, forelimb flexion adduction, decreased muscle strength , neurological symptom score was significantly higher (7.80 ± 1.03 points ), TTC staining was measured infarct range (20.23 ± 5.81%), HE staining showed hippocampal CA1 pyramidal cells surrounding space to expand, edema, basically normal morphology . AST high and low dose treatment group on cerebral ischemia-reperfusion injury have a protective effect , compared with model group , AST high and low dose therapy can improve neurological function deficit disorder

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