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Relationship between Tumoral Vascularity with Doppler Sonography and MVD, Expression of VEGF in Primary Hepatocarcinoma

Author: ZuoLinPing
Tutor: YangLiXia
School: Zhengzhou University
Course: Medical Imaging and Nuclear Medicine
Keywords: Primary liver cancer Color Doppler Power Doppler Microvessel density Vascular endothelial growth factor Immunohistochemistry Resistance index
CLC: R735.7
Type: Master's thesis
Year: 2005
Downloads: 68
Quote: 0
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Abstract


The purpose of primary liver cancer is a common malignancy , rapid growth, can occur early intrahepatic or extrahepatic metastasis characteristics . Newborn tumor vasculature is a key factor in the growth and metastasis of liver cancer , liver cancer vascular distribution characteristics of blood supply in an important role in the diagnosis , treatment and prognosis of liver cancer . In this study, using color Doppler flow imaging (Color Doppler Flow Imaging, CDFI), color Doppler energy imaging (Color Power Angio, CPA) and pulsed Doppler (Pulsed wave Doppler, PW) of blood flow to the liver testing, designed to reflect the blood supply of the tumor through tumor vascular imaging hemodynamic characteristics , and microvessel density ( microvessel density , MVD ) , vascular endothelial growth factor (Vascular Endothelial Growth Factor, VEGF) compared explore the relationship between the evaluation of angiogenesis activity and clinical parameters , and determination to provide an objective basis for clinical treatment and prognosis . Methods CDFI , PW, CPA detected 32 cases of primary liver cancer (29 cases of hepatocellular carcinoma , 1 case of mixed cancer a biliary cell carcinoma ) were observed within the tumor blood supply , to choose satisfactory image storage for analysis . 32 cases of liver cancer is divided according to the size of the diameter of small hepatocellular carcinoma type ( tumor diameter ≤ 3cm) the 6 cases nodular type ( 3cm lt ; the mass diameter ≤ 10cm) of 18 cases and bulky type ( tumor diameter gt ; 10cm ) 8 cases, according to the presence or absence of the portal vein , inferior vena cava , abdominal lymph node metastasis in one of those , divided into two groups , the transfer of 7 patients , 25 patients without metastasis . In all cases , fasting for 12 hours , supine position or left lateral position , two-dimensional and color Doppler ultrasound . A two-dimensional ultrasound observation liver tumor size , shape , location , internal echo . In the case of image display clear , measuring the longest diameter and the shortest diameter , whichever is the average value as the diameter ( D ) of the tumor . Conventional displayed under

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CLC: > Medicine, health > Oncology > Gastrointestinal Cancer > Liver tumors
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