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The background and purpose of coronary heart disease morbidity and mortality in developed countries first. With the improvement of living standards , the incidence of coronary heart disease in China was increasing year by year . The usually considered myocardial cell is the end point of cell differentiation , regeneration and the ability to repair the damage , in the event of myocardial infarction , myocardial viability cells through cell hypertrophy rather than cell proliferation compensatory . A large number of necrotic myocardium can only be filled by fibroblasts and lead to regional myocardial systolic dysfunction , heart failure , and ultimately scar tissue replacement . The current treatment , although you can save endangered necrotic myocardial cells , cardiomyocytes necrosis was powerless to do anything , can not solve the functional cardiomyocytes decrease in the number of fundamental issues , so we must find a more effective treatment . In recent years, the view of myocardial cells can be regenerated to break the antiquated concept that people can not regenerate the myocardium has consistently held that , which prompted researchers to explore all possible to promote myocardial cell regeneration and proliferation approach to the treatment of myocardial injury and heart failure . Currently , stem cell transplantation in the treatment of severe myocardial injury and end-stage heart failure has become a new hotspot , which bone marrow mesenchymal stem cell transplantation in the treatment of myocardial injury a lot of attention . Stem cell transplantation as a new therapy to improve the prognosis of patients with myocardial infarction , either directly or indirectly enhanced the contractile function of the heart . Source of difficulties and immunosuppressant use autologous stem cell transplantation . So far, the transformation of embryonic stem cells (embryonic stem cells, ES), bone marrow mesenchymal stem cells (mesenchymal stem cells, MSCs) and skeletal muscle stem cells (skeletal muscle stem cells) used in the study reported that the regeneration or replacement of damaged myocardium . Theoretically, to reach the wound area , the more the number of transplanted cells , the therapeutic effect is the more obvious ,
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