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Background and Purpose : Acute leukemia is a malignant clonal hematopoietic stem cell disease , significantly characterized by excessive proliferation and apoptosis inhibition . A variety of oncogenes, tumor suppressor genes and their related genes and the regulation of apoptosis gene dysfunction can lead to malignant cell proliferation and apoptosis by blocking ; same time , the body of abnormal cells in immune surveillance , the two jointly laid the incidence of leukemia foundation. β-catenin (β-catenin) is a signaling molecule found in recent years , it is a multifunctional protein , pass proliferation and differentiation signals in cell adhesion and Wnt ( cell protein) signaling from role in the tumor cells , promoting cell proliferation , inhibition of apoptosis . Ki-67 is a proliferating cell nuclear antigen, appears on the outside of Go G1 , S , G2, and M phase of the cell cycle , is to determine the activity of a specific marker of cell proliferation . Tumor necrosis factor-related apoptosis -inducing ligand (TNF-related apoptosis-inducing ligand, TRAIL) is a new member of the TNF superfamily , with its specific death receptor binding and activation of multiple apoptotic signaling pathways induced cell withered course , TRAIL and its receptors in tumor surveillance play an important role in apoptosis induced by TRAIL on the vast majority of human tumor cells , normal cells insensitive ; variety of immune surveillance cells such as CD4 ( ) cells , NK cells , macrophages, and dendritic cells , at least in part, dependent on the expression of TRAIL to play a cytotoxic effect , and inhibition of tumorigenesis and metastasis . the role of β-catenin in the tumors of epithelial origin has been basically clear , and its role in malignant disease of the blood system is just beginning : abroad concentration of β-catenin in leukemia cell lines and leukemia cells research is still less domestic reported no relationship between β - catenin and leukemia research
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