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Polyunsaturated Phosphatidylcholine for Liver Disease: A Systematic Review

Author: HuGuoPing
Tutor: ZhaoLianSan
School: Sichuan University
Course: Internal Medicine
Keywords: Polyene phosphatidyl choline Liver disease Viral Hepatitis Alcoholic liver Chronic hepatitis System Evaluation Randomized controlled trials Meta- analysis
CLC: R575
Type: Master's thesis
Year: 2004
Downloads: 182
Quote: 0
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Abstract


The purpose of the theory and methods of use of evidence-based medicine to evaluate the efficacy and safety of Essentiale the treatment of liver diseases . Method electronic and manual searches collect Essentiale with placebo / no treatment compared to the treatment of liver disease randomized controlled trials (randomized controlled trial, RCT) literature , not blinded , publication status and language restrictions . The documentary quality assessment consider four parts : random allocation method , allocation concealment , blinding, loss and loss-to-follow descriptions of the number and causes . Two reviewers independently Assessment of methodological quality and extracted the data. Qualitative analysis , or meta - analysis, sensitivity analyzes and subgroup analyzes necessary information extracted . The sensitivity analysis will be carried out in accordance with the following criteria : get rid of low - quality RCT , remove the short-term treatment of RCT and RCT remove small samples . RCT is divided into two sub- groups of viral hepatitis, alcoholic fatty liver , according to the cause of the Meta- analysis , Meta-analysis of the subgroup of chronic hepatitis established in accordance with the course of the disease . Cochrane Collaboration special package (RevMan4.2) the statistical analysis of the data . Results A total of 1694 literature contains 1785 patients met the inclusion criteria for the study were assessed 20 randomized controlled trials . 15 is a high-quality test, the rest are

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CLC: > Medicine, health > Internal Medicine > Digestive and abdominal diseases > Liver and gall bladder disease
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