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Objective : CNS (central nervous system, CNS) infection morbidity , mortality , morbidity are high, a serious threat to children 's lives and health . Its pathogenesis and pathophysiology of complex , it is not entirely clear, blood-brain barrier damage in the central nervous system infection plays an important role in its research become one of the hotspots . Select this topic purulent meningitis and viral encephalitis in children for the study, testing serum and cerebrospinal fluid matrix metalloproteinase (MMP-2, MMP-9) changes in the level and through the analysis for comparison with the control group , investigate MMP-2, MMP-9 in the central nervous system infections BBB injury in rats to evaluate MMP-2, MMP-9 on the central nervous system infection early diagnosis, determine the condition , analyze prognostic practical value. Method: 1 Experimental groups : purulent meningitis group ( referred to meningitis group ) 18 cases , including 11 males and 7 females , aged 6 months to 13 years , 18 cases of cerebrospinal fluid culture positive in 2 cases , cerebrospinal fluid culture negative clinical purulent meningitis diagnosed 16 cases ; viral encephalitis group ( referred to brain disease group ) 22 cases , including 10 males and 12 females , aged 6 months to 14 years old ; control group of 20 cases, including 12 males and females 8 cases , ages 6 months to 12 years old, are excluded from the same period the central nervous system infection hospitalized children . 2 detection indicators: serum , cerebrospinal fluid MMP-2, MMP-9 and serum , cerebrospinal fluid albumin . Results:
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