Dissertation > Excellent graduate degree dissertation topics show

Investigation of the Effect of Insulin on ICAM-1, VCAM-1 in Endothelial Cell

Author: LiuZhaoChuan
Tutor: WangXuKai
School: Third Military Medical University
Course: Internal Medicine
Keywords: Inslin Endothelial Cell sICAM-1 sVCAM-1
CLC: R587
Type: Master's thesis
Year: 2006
Downloads: 114
Quote: 0
Read: Download Dissertation

Abstract


Background:Artherosclerosis (AS) is a common and frequently disease which is associated with a significant morbidity and mortality. Coronary heart disease (CHD) is one of the main causes of premature death in industrialized countries, and its prevalence has been increasing in developing ones. Recent studies provide evidence that an inflammatory reaction is an essential component in the appearance and development of the atherosclerotic lesion. inflammatory cells roll along and adhere to blood vessel endothelium, and meanwhile penetrate through endotheliocyte while releasing various active cell material that causes proliferation of vascular smooth muscle cells, forming foam cell, and finally leading to AS. ICAM-1 and VCAM-1 both belong to Cellular adhesion molecules (CAMs), investigation shows that ICAM-1 and VCAM-1 play an important role in cardiovascular disease. Insulin has recently emerged as a significant vascular hormone with important links to the pathophysiology of atherosclerotic vascular disease. Vascular endothelium is the main organ under the influence of INS, and INS plays an important part in maintaining the normal function of blood vessel endothelium. It is proved by experiment that internal hyperinsulinemia causes the externalization disproportion of vascular endothelial cell ET-1 and NO, promotes the occurrence and development of DM blood vessel complication, and becomes the main factor of AS. Does hyperinsulinemia correlate with endotheliocyte adhesion molecule during the formation and growth of AS? This article will focus on animal model and molecular level, and tries to provide a new theoretical base for exploring the function of hyperinsulinemia in AS.Objective:1. To observe the influence of hyperinsulinemia on the expression of VEC VCAM-1 and ICAM-1 in the experiment;2. To observe the influence of INS on the expression of human VEC VCAM-1 and ICAM-1.

Related Dissertations

  1. Relaionship among Expression of ESM-1, VEGF-D, Lymphangiogenesis and Lymph Node Metastasis in Human Invasive Lobular Breast Cancer,R737.9
  2. The Effect of Drug-Containing Serum of RAS on Cell Viability of Huvec Oxidative Damage Model by H2O2 Induced,R285
  3. The Effect of Drug-Containing Serum of Slr on Cell Viability of Huvec Oxidative Damage Model by H2O2 Induced,R285
  4. Covalent Immobilization of Fibronectin on a Plasma Ploymeric Acrylic Acid Film and Its Behavior of Adhesion and Proliferation,R318.08
  5. Preliminary study the pathogenesis of coronary vasodilator,R543
  6. Inhibitory Effect of Extract of Grub Experimental on Choroidal Neovascularization in a Rabbit Model and Mechanism Investigation,R285.5
  7. The Research of Tumor-derived EGFL7 Effect on Human Umbilical Vein Endothelial Cell Biology Behavior,R735.2
  8. The Study on the Effects of Nickel in Ambient PM2.5 to the Circulate Vascular Endothelial Cells,R54
  9. Study of Injury Mechanism of Seawater Immersion on Vascular Endothelium Cells,R82
  10. The Compatiblity Study of Surface-modified PHBHHx in Vitro,R318.08
  11. The Empirical Study on the Effect of the RPF Containing-serum on the Endothelium Cell of Blood Vessel and Its Correlation Factors Injured by Ox-LDL,R285.5
  12. Relationship of Advanced Glycation End Products(AGEs) and Receptor of Advanced Glycation End Products(RAGE) and the Effect of High Glucose and AGEs on Vessel Cell,R587.1
  13. The Influence of Long-Term Inhaled Glucocoticoids on the Adhesion Molecular System of Bronchial Asthmatic Children,R725.6
  14. Effects of Alcohol on Promoting Apoptosis of Vascular Endothelial Cells in Rats,R363
  15. Expression of PD-ECGF in Nephroblastoma and Its’ Clinical Significance,R737.11
  16. Effect of Angiogenesis Inhibitors, IFN-α and IFN-γ on Lymphangiogenesis,R329
  17. 17-β Estradiol Can Protect Endothelial Cell from Apoptosis and Enhance mRNA Expression of MT1-MMP in Endothelial Cell under High Glucose Condition,R587.2
  18. The Protective Effects and Mechanisms of Isorhamnetin on Oxidized Low-density Lipoprotein Induced Endothelial Cell Injury in Vitro,R285
  19. The Effection of PLGA Scaffold Contain the Simvastatin in Construction of Vascularize Artificial Bone,R782.2
  20. Roles of Nuclear Factor-κB in Apoptosis of Endothelial Cells,R54
  21. Study of Surface Modification of Biomedical Microcoil Materials,TG174.4

CLC: > Medicine, health > Internal Medicine > Endocrine diseases and metabolic diseases > Islet disease
© 2012 www.DissertationTopic.Net  Mobile