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Research of the Expression of the SYK Gene in Human Colonic Carcinoma

Author: WanWei
Tutor: WuXiaoPeng
School: Shandong University
Course: Surgery
Keywords: colonic carcinoma Syk gene RT-PCR
CLC: R735.34
Type: Master's thesis
Year: 2006
Downloads: 82
Quote: 0
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Abstract


Background:Spleen Tyrosine (Y) Kinase (Syk) is a protein-tyrosine kinase whose expression has been found in various cells such as the hematopoietic,lymphocyte,fibroblast and vascular endothelial cells. Human Spleen Tyrosine (Y) Kinase (Syk)locus was mapped to be chromosome 9 at band q22,made up of 629 amino acids, molecular weighted 72KD.Syk gene is considered as a candidate anti-oncogene.Syk expression in colonic carcinoma was not reported.Objective:To evaluate the effects of the Syk gene expression in human colonic carcinoma on tumor growth and metastasis.Methods:The expression of Syk gene in the 40 fresh freezed tissues of colonic carcinoma patients(tumor tissues,adjacent normal tissues)was detected by RT-PCR technique.ResuIts:All nomal colonic tissues were detected the expression of the Syk gene.Compare to nomal tissues,27out of40 colonic carcinoma did not show any detectable Syk expression.And there were

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CLC: > Medicine, health > Oncology > Gastrointestinal Cancer > Intestinal neoplasms > Colorectal tumors
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