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Changes of Thyroid Function Effect on Outcomes of Pregnancy and Expression of Iodothyronine Deiodinase

Author: XuYanHong
Tutor: WuYiJie
School: Shanghai Jiaotong University
Course: Internal Medicine
Keywords: Gestation Thyroid function Thyroid peroxidase antibodies Deiodinase
CLC: R714.25
Type: Master's thesis
Year: 2007
Downloads: 160
Quote: 0
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Abstract


Thyroid function during pregnancy and autoimmune status change to the adverse effects on pregnant women and their offspring has received extensive attention , pregnancy whether it should become a hot topic in the routine screening of thyroid function and antibody . This topic for prenatal care in hospital obstetrics at the period from March 2006 to February 2007 , 632 cases of pregnant women who had no history of thyroid disease , thyroid function screening and obstetric complications observed , in some cases placenta, uterine tissue iodide thyroid thyroxine deiodinase detection . The results show that the downward trend with increasing gestational age , pregnant women, FT3, FT4 level , but no significant differences ( P gt ; 0.05) . In the past this group of pregnant women with no thyroid history , clinical and subclinical thyroid disease prevalence rate was 11.87% , subclinical hyperthyroidism was 0.16% (n = 1 ) , subclinical hypothyroidism was 6.80% ( 43 cases ) , clinical A reduced to 1.90% ( 12 cases ) , low Hypothyroxinemia of 3.01% ( 19 cases ) ; 7.75% TPOAb -positive pregnant women . In subclinical hypothyroidism in pregnant women fetal distress prevalence was 11.63% ; the group Hypothyroxinemia , intrauterine growth retardation prevalence was 10.53% , higher than the normal control group . Normal thyroid function , TPOAb positive group intrauterine growth retardation prevalence was 4.65% , only 0.58% and TPOAb negative . Maternal TSH levels associated with fetal distress than patients without complications , premature than those of patients without complications dropped . Placenta , uterus deiodinase detected by RT-PCR method , found that pregnant women, uncontrolled hypothyroidism Ⅱ type deiodinase enhanced expression of type III deiodinase weakening ; previous history , but prenatal control with no significant differences in normal control . The results of this study suggest that abnormal thyroid function and autoimmune state is closely related with a variety of obstetric complications . Uterus , placenta deiodinase may be related to the mother and fetus between the level of thyroid hormone regulation . Thyroid function during pregnancy and antibody screening helps early detection including clinical , especially subclinical thyroid disease , and provide timely treatment to improve obstetric prognosis .

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CLC: > Medicine, health > Obstetrics and Gynaecology > Obstetrics > Pathological pregnancy ( abnormal pregnancy ) > Complications of pregnancy
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