|
Purpose of detecting obstructive sleep apnea hypopnea syndrome (Obstructive sleep apnea-hypopnea syndrome, OSAHS) serum vascular endothelial growth factor (Vascular endothelial growth factor, VEGF), nitric oxide (Nitrogen monoxidum, NO), erythropoietin (Erythropoietin, EPO) and plasma carbon monoxide (Carbon monoxide, CO) levels, and to discuss its clinical significance. Method snoring coming to our hospital from September 2006 to March 2007, parallel multi polysomnography testing confirmed 64 cases of OSAHS patients, and in accordance with the apnea hypopnea index (Apnea-hypopnea index, AHI) is divided into a control group (5 times / h ≤ AHI ≤ 20 / h), 13 males and 7 females, mean age 47.9 ± 14.4 years, AHI 12.3 ± 5.1; OSAHS group (AHI gt; 20 times / h), 30 males, 14 females, mean age 46.1 ± 12.5 years, AHI 62.5 ± 22.5. (Next morning) after the end of the PSG of collecting blood samples, the application of ELISA, serum VEGF serum NO, nitrate reductase method, sodium dithionite reduction method determination of plasma CO RIA competitive method for the determination of serum EPO. Results ① in OSAHS group compared to the control group, the the OSAHS group of body mass index, neck circumference and waist circumference higher than that in the control group, the difference was statistically significant (respectively P lt; 0.05, P lt; 0.01 and P lt; 0.01); between the two groups age, gender and Hip difference was not statistically significant (P gt; 0.05). ② O SAHS group compared with the control group, the the OSAHS group of AHI, oxygen desaturation index, SpO2 lt; 0.9 time the percentage of total sleep time (%) was higher than that in the control group, the difference was statistically significant (P lt; 0.01); minimum night SpO2 lower than the control group, the difference was statistically significant (P lt; 0.01). ③ O SAHS group and the control group, the the OSAHS group of serum VEGF and plasma CO levels higher than that in control group, the difference was statistically significant (P lt; 0.05); significantly higher serum levels of NO in OSAHS group, the difference was statistically significance (P lt; 0.01); no significant change in serum EPO levels between the two groups, the difference was not statistically significance (P gt; 0.05). ④ respectively serum VEGF, NO, EPO and plasma CO indicators linear correlation analysis, the results showed that: VEGF with AHI, oxygen desaturation index, SpO2 lt; 0.9 time the percentage of total sleep time (%) showed a significant positive correlation (respectively, r = 0.261, P = 0.037; r = 0.267, P = 0.033; r = 0.272, P = 0.030), and nighttime minimum SpO2 was a significant negative correlation (r = -0.375, P = 0.002); NO carotid Wai, AHI, oxygen desaturation index and SpO2 lt; 0.9 time accounted sleep time percentage (%) was significant with are related (respectively for r = 0.283, P = 0.036; r = 0.336, P = 0.007; r = 0.353, P = 0.004 r = 0.385, P = 0.002), and nighttime minimum SpO2 was a significant negative correlation (r = -0.313, P = 0.012); CO and body mass index, neck circumference, waist circumference, AHI, oxygen desaturation index and SpO2 lt; 0.9 total sleep time percentage (%) was significantly positively correlated (r and P, respectively 0.249,0.342,0.297,0.366,0.370,0.362 and 0.047,0.011,0.028,0.003,0.003,0.003) and nighttime minimum SpO2 was a significant negative correlation (r = -0.341, P = 0.006); present study found no relationship (P gt EPO and indicators; 0.05). ⑤ stepwise multiple regression analysis showed that night minimum SpO2 levels affect serum VEGF, plasma CO levels were independent risk factors (respectively R2 = 0.198, P = 0.001; R2 = 0.210, P = 0.000), SpO2 lt; 0.9 time accounted sleep The percentage of time (%) is an independent risk factor for serum levels of NO (R2 = 0.148, P = 0.004); found no independent risk factors affect serum EPO levels. Conclusion ① severe OSAHS patients with serum VEGF, NO and plasma CO levels higher than the mild OSAHS patients, VEGF, NO and CO were associated with AHI, oxygen desaturation index, SpO2 lt; 0.9 time total sleep time percentage (%) was significantly positively related The night minimum SpO2 was a significant negative correlation. The night minimum SpO2 levels affect OSAHS patients serum VEGF, plasma CO levels were independent risk factors, SpO2 lt; 0.9 time total sleep time percentage (%) is an independent risk factor for OSAHS patients serum levels of NO, suggesting Hypoxemia situation is to promote The main reason for the rise of OSAHS patients with serum VEGF, NO and plasma CO. OSAHS patients with serum VEGF, NO and plasma CO levels may to some extent to improve the situation of ischemia and hypoxia and lower blood pressure, reduce the OSAHS related cardiovascular disease incidence, which may have a very important role in protecting the body. ② in the severe OSAHS mild OSAHS patients between serum EPO levels no significant changes in its possible causes need to be further confirmed.
|