Dissertation > Excellent graduate degree dissertation topics show

Curcumin Inhibits the Proliferation of Airway Smooth Muscle Cells in Airway Remodeling and Its Mechanism

Author: ZhangTingTing
Tutor: XuJiDe
School: Guangzhou Medical College
Course: Pathology and pathophysiology
Keywords: Bronchial asthma Airway remodeling Airway smooth muscle cells Curcumin Mice
CLC: R285
Type: Master's thesis
Year: 2010
Downloads: 36
Quote: 0
Read: Download Dissertation

Abstract


Objective: airway smooth muscle layer thickening of the pathological changes is important pathological features of airway remodeling. The study found that airway remodeling in asthma patients (especially with moderate to severe asthma), an increase in the number of airway smooth muscle cells (hyperplasia) or cell hypertrophy, which leads to the thickening of the smooth muscle layer. Factors thickening of airway smooth muscle cells (Airway smooth, Muscle cells ASMCs was examined) hyperplasia is predominant. This study was prepared BALB / c mice with chronic asthma airway remodeling model to study the inhibitory effect of curcumin on proliferation of ASMCs, to explore the possible signal transduction mechanisms and drug targets. : Ovalbumin (OVA) sensitization and challenge of SPF BALB / c mice to establish mice with chronic asthma airway remodeling model. The mice were observed when excited symptoms; detection of airway responsiveness; ELISA assay of serum specific IgE content; eosinophils accounted for a percentage of the total number of white blood cell counts in bronchoalveolar lavage fluid (BALF); pathological observation airway structural changes ; using immunohistochemical identification of airway smooth muscle and image analysis software IPP measured bronchial wall thickness and the thickness of the smooth muscle layer. Results: 1 mouse model of excitation early irritability, shortness of breath, salivation, abdominal cramps and incontinence positive, curcumin prevention and treatment groups obvious symptoms, symptoms late, and to ease soon, asymptomatic normal control group. 2 curcumin prevention and treatment groups airway reactivity was significantly lower than the asthma group, P lt; 0.05, but still higher than the control group, P lt; 0.05. 3. Of curcumin Prevention and treatment groups serum specific IgE was significantly lower than the asthma group, P lt; 0.05, but still higher than the control group, P lt; 0.05 4. curcumin prevention and treatment groups in BALF eosinophils accounted for a percentage of the total number of white blood cells were significantly lower than asthma group, P lt; 0.05, but still higher than the control group, P lt; 0.05. 5 bronchial wall thickness of curcumin prevention and treatment groups, the bronchial smooth muscle layer thickness and number of bronchial smooth muscle cells were significantly lower than the asthma group, P lt; 0.05, but still higher than that in control group, P lt; 0.05. Conclusion: 1. Successfully established airway remodeling model. 2 curcumin can significantly reduce activity in mice, airway hyperresponsiveness, serum-specific IgE in BALF fluid eosinophils accounted for a percentage of the total number of leukocytes and reversing airway remodeling pathological changes. Curcumin can inhibit airway remodeling model of airway smooth muscle proliferation. Curcumin inhibition of proliferation of ASMCs may be associated with the inhibition of ERK1 / 2 signaling pathway.

Related Dissertations

  1. Preliminary Study of Phosphorylation Effect on UGT1A3 Metabolism Activity Towards Drugs,R346
  2. Study of Sepia Ink-Astragalus Preparation for Relieving Damage Caused by Chemotherapy,R285.5
  3. Effects of Angiogenic Factor on Follicular Angiogenesis and Development in Immature Mouse,S865.13
  4. Study on Gene Expression of β-defensin1 in Mammary Gland of Mice,S852.4
  5. Roles of MMP-7 and Lysozyme in the Pathogenesis of Ulcerative Colitis Induced by DSS in Balb/c Mice,S858.91
  6. Some Pharmacology and Toxicity of Three Prescriptions from Chinese Veterinary Pharmacopoeia,S859.5
  7. Study of Melittin on Tumor Inhibition and Part of Mechanism of Human Hepatocellular Carcinoma HepG-2 Xenograft in Nude Mice,R735.7
  8. Apolipoprotein E Gene Knock-out and High-fat Diet on IP3、 IP3R-1 ＆ Aβ Expression in Neurons of Mice’s Hippocampal CA1 ＆ Ca3,R329
  9. Effects of TACI-Ig on MRL/lpr Mice and Activation of JAK1-STAT1 Signaling Pathway in Lupus Nephritis,R363
  10. The Influence of Early Intervention of Vitamina Combined with Mycobacterium Bovis Bacillus Calmette-Guerin on Lung CD11C+ and Anti-OVA Special IgE Expression in Adult SD Mice Asthma Model,R562.25
  11. The Influence in Different Route of Medication with Vitamin A on CD4~+CD25~+ Regulatory T Cell and Cell Factor of IL-4、 IFN-γ in a Rat Persistent Asthma Model,R562.25
  12. Effects and Some Mechanisms of TACI-Ig on Immune Function in MRL/lpr Mice,R593.241
  13. Maternal Exposure to Fenvalerate in Embryo Accelerated Age-related Changes of Behaviors in CD-1 Mice,R714.2
  14. The Experiment Study Was Used Three Methods to Repair the Ligation of the Femoral Nerve,R651.3
  15. Effects of Aspirin and Curcumin on COX-2, β-attention and PGE2 Expressions in Colon Cancer Cell Lines of HT-29 and SW 480 Cells,R735.35
  16. Effect of Curcumin on Hippocampal No-Nos System of Growing Pigs Subjected to Transport Stress,S858.28
  17. Effect of β-elemene Combined with Radiotherapy on the Angiogenesis of Lung Adenocarcinoma Xenograft Tumor in Nude Mice,R734.2
  18. Antitumor Effects of Elemene on the Proliferation Inhibition and Apoptosis Induction in Ascites Hepatoma Cell Line H22,R735.7
  19. The Experimental Research of RNAi Technology Inhibiting Respiratory Syncytial Virus,R725.6
  20. Study on the Correlation Between the Levels of Il-18, IL-33 and Other Inflammatory Factors and Pulmonary Function in Different Stages of Asthma,R562.25
  21. A Stuty on the Diversification of Interleukin-17 of Asthma Mouse and the Affection of the Treament of Glucocorticoids,R562.25

CLC: > Medicine, health > Chinese Medicine > Of Pharmacy > Pharmacology
© 2012 www.DissertationTopic.Net  Mobile