Dissertation > Excellent graduate degree dissertation topics show

The Effect of Kang Xian Zeng Zhi Pellet on the Activity of NMDA Receptor in Brain of Kinding Model Rats and Their Studying Memory in Water Maze

Author: YaoFengLi
Tutor: MaRong
School: Tianjin College of Traditional Chinese Medicine
Course: Chinese Academy of Pediatrics
Keywords: The antiepileptic Zengzhi particles Kindling model rats Water maze NMDA receptor binding capacity
CLC: R285.5
Type: Master's thesis
Year: 2003
Downloads: 122
Quote: 0
Read: Download Dissertation

Abstract


Objective: To explore traditional Chinese medicine anti-epileptic lit on the pentylenetetrazol (Pentylenetetrazole, PTZ) induced rat models of NMDA receptor activity and increased intelligence particles in the water maze learning and memory abilities. : Sub-convulsive dose of PTZ (32mg/kg) by intraperitoneal injection induced kindling attack, screening V class VI attack rats as experimental subjects were randomly divided into model group, low dose group of anti-epileptic, anti-epileptic high-dose group and western medicine group, take another eight normal rats as control. The following observations: 1, behavioral observation;, learning, memory capacity test; 3, the cerebral cortex, hippocampus NMDA receptor binding capacity test. Results: 1. Behavioral experiments: anti-epileptic Zengzhi particles can significantly against seizure kindling model in rats, the attack level and latency with the model group were compared to the significant difference P <0.05, its anticonvulsant effects of the drug dose relevant. Compared to the traditional Chinese medicine group and western medicine group the difference was not significant P> 0.05. 2 NMDA receptor binding capacity experiment: Compared with normal control group, model control group NMDA receptor activity was significantly increased, the difference was significant P <0.05 . Compared with the model group, the anti-epileptic low-dose group, the anti-epileptic high-dose group, sodium valproate group of NMDA receptor activity reduced, but the difference was not significant; compared with the normal control group, model control group cortex NMDA receptors body activity was significantly increased, the difference was significant P <0.05. Compared with the model group, cortical NMDA receptor activity of anti-epileptic high-dose group, sodium valproate group of NMDA receptor activity was significantly lower, the difference was significant P <0.05, low-dose group of anti-epileptic NMDA receptor activity was reduced, but the difference was not statistically significant. 3 water maze test results show that: the water maze test results show that the model group looking for a platform for the required time (22.8 ± 9.1s) than the normal control group (8.5 ± 4.1s) significantly increased the difference was significant P <0.05. Compared with the model group, Chinese high-dose group looking for a platform for the required time (9.5 ± 7.6s) was significantly shorter than the model group (22.8 ± 9.1s) difference significant P lt; 0.05. The time required for the low dose group (11.9 ± 6.0s), sodium valproate group (13.5 ± 4.8s) compared with the model group shortened, but the difference was not statistically significant. Conclusion: Chinese medicine preparations of anti-epileptic Zengzhi particles can be effective against seizures kindling model in rats, the attack level to reduce latency; improve learning and memory function kindling model in rats; its function may be associated with the regulation of NMDA receptor activity .

Related Dissertations

  1. Domestic isoflurane inhalation anesthesia effect depends on learning and memory in adult rats related research,R965
  2. The Extraction of Swim Bladder of Miiuy Croaker Collagen and It’s Effect on Learning and Memory in Mice,R285.5
  3. The Effect of Yuxianling Granula on the Learning and Memory, Hippocampus MFS of KA Induced Temporal Lobe Epilepsy in Rat,R742.1
  4. The Biochemical Mechanisms of Audiogenic Epilepsy in FMR1 and the Intervention Effect of Bupleuri and Ramuli Cinnamomi Decoction,R742.1
  5. The Effect of Intermittent Hypoxia on the Function of Learning and Memory and Cerebral Ultramicrostructure in Rats,R363
  6. The Ameliorative Effect and Mechanism of Procyanidins Extracted from the Lotus Seedpod on Age-associated Memory Impairment in Rats,R285.5
  7. The Effect and Mechanism of Procyanidins Extracted from the Lotus Seedpod on Age-associated Memory Impairment in Rats,R285.5
  8. Study to the Effect of Angiotensin Ⅱ Type 1 Receptor Blockage on Learning and Memory and tau Protein Phosphorylation in Alzheimer Disease Animals,R749.16
  9. The Effects of Repetitive Transcranial Magnetic Stimulation and Its Mechanism Study on Ability of Learning and Memory in Mild Cognitive Impairment Rat Model,R749.16
  10. Effect of Neurosteriods on Learning and Memory Ability of Rats and Its Mechanisms,R749.16
  11. Adult Neurogenesis for Cognitive Function Repair after Graded Traumatic Hippocampus Injury,R651.1
  12. The Use of Mannitol for Bone Marrow Mesenchymal Stem Cells Transplantation,R749.13
  13. The Mechanism Study of QingNao Capsule in Treating Vascular Dementia,R285.5
  14. Ghrelin and Obestatin , on spatial learning and memory abilities of,R33
  15. The Study on Effect of Propofol Induce Sleep Treatment on the Chronic Insomnia Patients,R740
  16. Limit load movement NCAM mRNA expression in rat frontal impact their spatial memory,G804.2
  17. Study of Behavior, Pathology and Cytoskeletal Protein in Vacular Dementia Rats Induced by Chronic Cerebral Ischemia,R749.16
  18. The Research on the Protective Effects and Mechanism of Tenuigenin to the Mice and PC12 Cells Model of Alzheimer’s Disease Induced by Aβ1-40,R285.5
  19. Transplantation of Bone Marrow Mesenchymal Stem Cells in Treatment of Alzheimer’s Disease in Rats,R749.16
  20. 2 - 1 - (4 - pyridyl) ethoxy acetic acid esters synthesis and the role of learning and memory in mice,R96
  21. Experimental Study of Biological Effects of Electromagnetic Radiation,TM937

CLC: > Medicine, health > Chinese Medicine > Of Pharmacy > Pharmacology > Chinese medicine Experimental Pharmacology
© 2012 www.DissertationTopic.Net  Mobile