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Theories and methods for the establishment of of colorectal tissue optical model

Author: CaoXing
Tutor: ZhangYangDe
School: Central South University
Course: Biomedical Engineering
Keywords: Colorectal cancer Laser-induced fluorescence Optical model Diffuse reflection The intrinsic fluorescence Spectroscopy
CLC: R318.51
Type: Master's thesis
Year: 2004
Downloads: 55
Quote: 0
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Abstract


Early detection and localization of the tumor is the key to improve the cure rate of cancer and save the lives of the majority of cancer patients . Laser spectroscopy to distinguish human tissue pathological state , is expected to overcome the main drawback of routine clinical testing means to achieve real-time tumor tissue , non-destructive and quantitative in vivo detection and location . National \The research topics include : 1 . Use of the theory of laser transmission in human tissue analysis useful for optical diagnosis of diffuse reflection approximation theory , proposed a three- parameter simplified analytical model based on Monte Carlo simulation based on iterative inverse push method can be used to obtain tissue diffuse reflectance optical parameters by measuring the tissue surface . 2. From the microscopic level, the establishment of tissue fluorescence excitation , emission and dissemination of mathematical model , using Monte Carlo simulation method and hierarchical colon tissue model , colon tissue autofluorescence under UV laser excitation emission simulation . The results showed that : from the mucous layer and submucosa of the large intestine tissue from more than 95% of the body fluorescence . 3. Organization since body fluorescence by tissue optical properties of modulation role , the design of a basis under the same light road measured was the diffuse reflection spectrum to restore the organization 's intrinsic fluorescence spectra of the algorithm , and through verification , thus fluorescence spectral characteristics of the analysis provided more accurate information . 4. Developed to facilitate the clinical use of high sensitivity , high signal-to-noise ratio of autofluorescence detection system , a human colon tissue in vivo and in vitro specimens experiment , pointed out that the spectrum of colorectal normal tissue and cancerous tissue autofluorescence spectra characteristic difference is peak position and peak intensity .

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CLC: > Medicine, health > Basic Medical > Medical science in general > Biomedical Engineering > Other branches of biomedical engineering > Light,laser biomedical
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