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Expression of TSP-1 and VEGF Related to the Metastasis and Prognosis of Human Pancreatic Cancer

Author: LinHai
Tutor: LiuRui
School: Second Military Medical University
Course: Surgery
Keywords: Thrombospondin -1 Vascular endothelial growth factor
CLC: R735.9
Type: Master's thesis
Year: 2007
Downloads: 119
Quote: 0
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Abstract


Objective: To study the TSP-1 and VEGF in pancreatic cancer prognosis . Methods: Using immunohistochemical methods to detect the expression and distribution of TSP-1 and VEGF in 74 cases of pancreatic cancer and 16 patients with paraneoplastic normal pancreas and chronic pancreatitis tissue data obtained SPSS11.0 software for statistical analysis of TSP -1 and VEGF expression in pancreatic cancer tissue judge pancreatic cancer metastasis and prognosis role . Results : ① TSP- 1 and VEGF expression in human pancreatic cancer and paraneoplastic normal pancreas and chronic pancreatitis tissue expression were significantly different . ② TSP-1 positive expression in patients with lymph node metastasis , perineural invasion , tumor stage, tumor size is a significant difference between patients with tumor tissue TSP-1 weakly positive and negative expression ; VEGF expression in tumor tissue , weak positive and negative expression patients with lymph node metastasis, perineural invasion . The ③ Logistic stepwise regression analysis showed that TSP -1 expression and tumor stage, metastasis nerve ; closely related to VEGF expression and lymph node metastasis and perineural invasion . The ④ Kaplan-Meier method and the log-rank test analysis of TSP -1 , VEGF closely related to lymph node metastasis, perineural invasion , tumor stage are significant in determining tumor prognosis . ⑤ multivariate Cox risk model analysis , perineural invasion , lymph node metastasis of tumor survival prognosis directly related to the role of TSP -1 and VEGF expression in the analysis is not directly related factors . ⑥ Kaplan-Meier method and the log-rank test analysis showed that patients with the worst prognosis when TSP-1 and VEGF positive expression . Conclusion : TSP-1 and VEGF can act as a judge of pancreatic cancer metastasis and prognosis factors , combined with the expression of TSP-1 and VEGF judge pancreatic cancer prognosis clinical value .

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CLC: > Medicine, health > Oncology > Gastrointestinal Cancer > Pancreatic tumors
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