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Synthesis, Antimicrobial Study of Platium (Ⅳ) Complexes with Compounds Containing N Groupand and the Interaction between the Complex and DNA

Author: LiQingPing
Tutor: SongYuMin
School: Northwest Normal University
Course: Inorganic Chemistry
Keywords: Nitrogen-containing heterocyclic Platinum (Ⅳ) Complexes Antibacterial activity DNA Intercalation
CLC: O641.4
Type: Master's thesis
Year: 2011
Downloads: 118
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Abstract


This paper imidazole, 2,2 - linked imidazole and phenanthroline as ligand synthesis of three binary complexes of nitrogen-containing heterocyclic platinum, and on this basis, introduction of a second ligand, synthesized two platinum phenanthroline ternary complexes by elemental analysis, IR, UV-vis and TGA - DTA and other analytical methods were used to characterize them, but also systematically studied three kinds of binary complexes of antibacterial activity and five kinds of complexes with DNA. This thesis includes the following four sections. 1 Overview section introduces the metal complexes anticancer and antimicrobial research progress, and nitrogen-containing heterocyclic nitrogen-containing heterocyclic compounds and their complexes were outlined, established the study of this subject content. Meanwhile summarizes the metal complexes with ct-DNA interactions and research methods. Finally this topic elaborated design ideas and research significance. (2) nitrogen-containing heterocyclic platinum (Ⅳ) Complexes Synthesis, Characterization and Antimicrobial Activity in mixed solvents containing heterocyclic synthesis of three platinum (Ⅳ) binary complexes by elemental analysis, molar conductance, IR , UV-Vis, TGA - differential thermal analysis and 1HNMR and other methods to determine the nitrogen-containing heterocyclic platinum (Ⅳ) complexes of the chemical composition, and speculated that its structure, while study their antimicrobial activity. Experimental results show that: Platinum (Ⅳ) imidazole complexes and platinum (Ⅳ) 2,2 '- biimidazole complexes on Escherichia coli, Staphylococcus aureus and Bacillus subtilis bacteria was significantly stronger than the corresponding ligand inhibition bacteria, especially E. coli, bacteria better, with broad-spectrum antimicrobial activity; while platinum (Ⅳ) phenanthroline complexes, although some antibacterial activity, but its antibacterial activity and ligand does not make much difference. 3 nitrogen-containing heterocyclic platinum (Ⅳ) binary complexes with DNA research ethidium bromide as fluorescent probes, using a combination of UV absorption and fluorescence spectroscopy and other characterization methods we studied with ct-DNA complexes interactions and explore its mechanism of fluorescence quenching process and calculate these compounds with DNA-EB binding constant K, binding sites n and thermodynamic parameters. By thermal denaturation and ionic strength experimental study, we hypothesized that the three kinds of nitrogen-containing heterocyclic platinum (Ⅳ) complexes with DNA binding mode mainly. Experimental results show that the three complexes all possible ways intercalation with DNA, strong and stable, leading to the destruction of the DNA double helix, it has some antibacterial activity, which is effective for the design of low toxicity Platinum (Ⅳ ) antitumor complexes provides a theoretical basis. 4 nitrogen-containing heterocyclic platinum (Ⅳ) Ternary Complexes Synthesis, Characterization and DNA interaction studies we synthesized Pt (Ⅳ) - phenanthroline - oxalic acid and Pt (Ⅳ) - phenanthroline - glycine two kinds of nitrogen-containing heterocyclic platinum (Ⅳ) ternary complexes were characterized by elemental analysis, molar conductance, IR, UV-Vis, and TGA - DTA and other analytical methods to determine their chemical composition and structure, and studied them with DNA interactions, research methods and the same binary complexes. Experimental results show that the two ternary complex is through the way with DNA intercalation strong and stable effect and binding constants greater than the corresponding platinum (Ⅳ) phenanthroline binary complexes with DNA binding constants, and further Description The second introduces enhanced ligand complexes with DNA binding strength.

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CLC: > Mathematical sciences and chemical > Chemistry > Physical Chemistry ( theoretical chemistry ),chemical physics > Structural Chemistry > Complex chemistry ( coordination chemistry )
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