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Mesoporous Materials: Synthesis and Application as Drug Carrier

Author: GaoChuanBo
Tutor: CheShunAi
School: Shanghai Jiaotong University
Course: Applied Chemistry
Keywords: Mesoporous materials Formation Mechanism Molecular Design Hard template Percutaneous administration
CLC: TQ460.1
Type: PhD thesis
Year: 2009
Downloads: 612
Quote: 1
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Abstract

Mesoporous material was first discovered in the early 1990s, is a set of physical, chemical, and materials for the integration of multi-interdisciplinary field. 2-50 nm uniform and controlled pore size, large specific surface area and pore volume characteristics it has potential applications in catalysis, separation, biomedical and other fields, has aroused wide interest of researchers. Mesoscopic structure and chemical composition of the mesoporous material is an important characteristic of mesoporous materials. The topological structure and chemical composition of the mesopores of the mesoporous material having different characteristics, and may produce different application prospects. Mesoporous materials structure formation mechanism is explained from different angles, but still not perfect. This article uses the anionic surfactant-oriented system to a more in-depth study of the formation mechanism of the mesoporous structure, pursuant to which the proposed new structure of control mechanism; hard template synthesis of metal oxide mesoporous materials; mesoporous material as a drug carrier, the development of a transdermal drug delivery system based on mesoporous materials. In the second chapter, this article uses anionic surfactant N-myristoyl glutamic acid (C14GluA) as templating agent, N-trimethoxy-silicon - acrylic yl-N, N, N-tris-dimethyl ammonium chloride (TMAPS ) as a co-structure-directing agent (CSDA), by changing the proportional relationship of the key components in the synthesis system, is drawn through a large number of experimental results anionic surfactant guide mesoporous materials (AMS), the synthesis of the phase diagram. Discussion of the distribution of the the synthetic phase diagram in the phase region, the paper systematically investigated the control mechanism of the mesoporous structure and proposed the following structure exists in the system control mechanism. (1) the organic / inorganic interface curvature determines the type of mesoporous mesoporous topology is bicontinuous, straight tubular or cage-like. Change of the organic / inorganic interface curvature can be surfactant accumulation constant g change to achieve. (2) in a cage-like mesoscopic phase formation process in mesoscopic electrostatic interactions between the cage has played a key role. Mesoscopic cage when the strong interaction between mesoporous cages piled performance as \closely packed and minimum surface area to decide its accumulation. Mesoscopic various \Interaction between the relatively strong system. Cage mesoscopic phase formation mechanism was first proposed. In Chapter III, the design strategy by the surfactant molecules, synthesis of a mesoporous material having a thick-walled structure. The alcohol used herein, an alkyl polyether carboxylic acid salts (AEC) type surface active agent as a templating agent, and by the segments of the polyoxyethylene (EO) and a carboxylic acid functional group in the molecule with a silicon species and CSDA hydrogen bonds and electrostatic interactions, synthetic mesoporous material having a double silicon wall structure. The material exhibits a larger pore wall thickness and high hydrothermal stability. In addition, through the AEC molecule EO average segment length control the wall thickness of the mesoporous materials fine-tuning. In the fourth chapter, through the hard template method use the the Co3O4 copy a different aperture SBA-15 (p6mm), KIT-6 (Ia-3d) and AMS-10 (Pn-3m) material, different structure Mesoporous Co3O4, and a preliminary study of the relationship between the template silica materials the pore size and spatial symmetry hard template synthesis of mesoporous metal oxide structure. We found that (1) When the SBA-15 and smaller aperture, the copy at the inverting Co3O4 mesoporous structure can not be maintained and there was obtained are separated from each other a single crystal nanowire; When the SBA-15 and the larger pore size case, the inverting copy obtained mesoporous Co3O4 maintained template the spatial structure of the mesoporous silica material, and can maintain the shape of the template material. (2) When the pore size of the KIT-6 material is small, simultaneous the Co3O4 copy Ia-3d structure double continuous bore, the single set of channels and the dual sets of channels. KIT-6 materials the pore size is large, Ia-3d structure of two sets of non-communication mesoscopic channels by Co3O4 fully replicated. (3) can be obtained AMS-10 the aperture range (5.1 nm - 6.7 nm), Co3O4 copied Pn-3m structure double continuous bore in double sets of channels and a single set of channels. The hard template replication method also provides the structural information of the template material, we found that the walls of the D surface of the AMS-10 along the growth of silica in the thinnest place, that may exist on both sides of the communicating D surface bicontinuous channels ordered micropores. In the fifth chapter, the development of a drug delivery system based on mesoporous materials with potential applications in the field of transdermal drug delivery. Used herein, fluorescein isothiocyanate (FITC) as a model drug, the first drug key bonded to penetrate the plasma membrane polypeptide (CPP), the drug has the ability to penetrate the cell membrane; then this compound is introduced into the organic and inorganic hybrid materials, to achieve the stability of the drug / CPP and a controlled release of the drug. The effectiveness of the method is in vitro release, matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOFMS) and cell experiments confirmed. The in vitro release experiments showed that the release curve is S-shaped, that the existence of the induction period and accelerate the release of three stages and release finished, the total release time of over 120 hours. This hybrid material containing FITC-CPP with cells co-cultured, FITC-CPP slow release and continue to penetrate the cell membrane into the cells, even after 96 hours clearly observed FITC signals within cells. This suggests that the use of mesoporous organic-inorganic hybrid materials to ensure the secure storage of drugs / CPP, the slow release of the drug / CPP, and cause the cells to the drug / CPP continued endocytosis. Therefore, the drug delivery system has potential applications in the field of transdermal drug delivery.

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