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The Studies on Nano-Sized Hydroxyapatite as Pharmaceutical Excipients

Author: GuoZhiHua
Tutor: MaYuQin
School: Changchun University of Science and Technology
Course: Inorganic Chemistry
Keywords: Hydroxyapatite Nano Pharmaceutical excipients
CLC: R943
Type: Master's thesis
Year: 2011
Downloads: 20
Quote: 0
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Abstract


This thesis is hydroxyapatite nanoparticles as drug excipients system . Chemical precipitation , sol - gel method and reversed-phase microemulsion synthesis of nano - hydroxyapatite and its characterization by infrared spectroscopy , X - ray diffraction , electron microscopy and other methods . Spectral properties, structure and morphology of the prepared samples tested to confirm three methods are successfully prepared hydroxyapatite nanoparticles . By light, temperature , humidity factors hydroxyapatite nanoparticles as pharmaceutical excipients stability were investigated , results showed that the hydroxyapatite nanoparticles have good stability . Nano - hydroxyapatite nano- hydroxyapatite PH value, liquidity , wet primer and a number of visits to establish quality standards . Again , by the acute toxicity test the toxicity of nano - hydroxyapatite were identified. Chemical precipitation , sol - gel method and reverse microemulsion method synthetic hydroxyapatite nanoparticles as evaluate the advantages and disadvantages of pharmaceutical excipients . The experiment showed that the hydroxyapatite nanoparticles non-toxic and can be used as the use of pharmaceutical excipients .

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CLC: > Medicine, health > Pharmacy > Pharmacy > Pharmaceutics
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