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Objective: To study children with primary nephrotic syndrome between T cell subsets and humoral immune TCM syndromes of liver and kidney certificate and spleen deficiency syndrome correlation. Studied in children with primary nephrotic syndrome correlation between T cell subsets and humoral immunity and pathological type of small lesions and mesangial proliferative lesions. The study of children with primary nephrotic syndrome T cell subsets and humoral immunity between correlation. Method: 1. Meet the age of primary nephrotic syndrome in hospitalized patients ≤ 18 years of age to check 24h urinary protein, plasma cholesterol, serum albumin, CD3, CD4 CD3 and CD8 CD3, CD4 / CD8 IgG , IgA, IgM, IgE, C3, C4 and other indicators, and select the TCM Syndrome Types of cases of liver and kidney certificate and spleen deficiency by renal biopsy to determine the patient's pathological type. 2 would meet the conditions of 40 patients were divided into liver and kidney syndrome group (n = 19) and spleen deficiency syndrome group (n = 21). In both groups follow a normal distribution and to meet the conditions of homogeneity of variance, with a group t test; not obey normal distribution or heterogeneity of variance, two groups were compared using the Wilcoxon rank sum test, CD3%, CD4 CD3% , CD8 CD3%, CD4 / CD8, IgG, IgA, IgM, IgE, C3, C4's differences. 3 would meet the conditions of 35 patients divided into tiny lesion group (n = 18) and mesangial proliferative lesion group (n = 17). In both groups follow a normal distribution and to meet the conditions of homogeneity of variance, with a group t test; not obey normal distribution or heterogeneity of variance, two groups were compared using the Wilcoxon rank sum test, CD3%, CD4 CD3% , CD8 CD3%, CD4 / CD8, IgG, IgA, IgM, IgE, C3, C4's differences. The children meet the conditions of 40 cases of patients with PNS CD3, CD4 CD3 and CD8 CD3, CD4 / CD8 using multiple linear stepwise regression method individually analyzed and IgG, IgA, IgM, IgE, C3, C4 correlation . Results: (1) the majority of children with primary nephrotic syndrome in patients with urinary protein, serum albumin, and cholesterol to meet the diagnostic criteria of primary nephrotic syndrome. 2.40 children PNS patients, the liver and kidney certificate 19 cases (47.5%), spleen deficiency syndrome in 21 cases (52.5%), MCD 18 cases (45.0%), MsPGN in 17 cases (42.5%), MPGN2 patients (representing 5.0%), MN 2 cases (representing 5.0%), FSGS1 cases (2.5%). 3 children PNS spleen deficiency syndrome patients the CD3% compared with the liver and kidney syndrome patients (P lt; 0.05); children PNS spleen deficiency syndrome patients CD8? 3% and liver kidney yin deficiency syndrome patients CD8 CD3% distribution different (P lt; 0.05); still can not believe that children PNS spleen deficiency syndrome patients with liver-kidney yin deficiency syndrome patients with CD4 CD3%, CD4 / CD8 different. 4. Still can not believe that children PNS spleen deficiency syndrome in patients with liver and kidney syndrome patients IgG, IgA, IgM, IgE, C3, C4, horizontal distribution differences. 5. Still can not believe that children PNS tiny lesions in patients with mesangial proliferative lesions CD3, CD4 CD3% and CD8 CD3%, CD4 / CD8 differences. 6 children PNS tiny lesions in patients with mesangial proliferative lesions in patients with IgG, IgA, IgM, IgE, C3, C4 levels. Still can not believe there are differences. 7 children PNS patients CD3% with IgE was card related (r = 0.330); CD4 CD3% and IgE was positive related (r = 0.371); CD4 CD3% and IgM was positive related (r = 0.482), and compared with CD4 CD3% and degree of positive correlation of IgE; of CD8 CD3% with IgM showed a positive correlation (r = 0.443); CD4 / CD8 IgM was positive correlation (r = 0.557). Conclusion: Children PNS spleen deficiency syndrome were CD3% compared with liver kidney yin deficiency syndrome patients, spleen deficiency syndrome in patients with liver and kidney syndrome were CD8 CD3% distribution, while CD4 CD3%, CD4 / CD8, IgG, IgA, IgM, IgE, C3, C4 no difference. 2 children PNS tiny lesions in patients with mesangial proliferative lesions CD3, CD4 CD3 and CD8 CD3, CD4 / CD8 of IgG, IgA, IgM, IgE, C3, C4 and no difference. 3 children PNS patients with IgE CD3% was positively correlated; CD4 CD3% IgE, IgM was positively correlated; CD8 CD3%, CD4 / CD8 was positively correlated with IgM.
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