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Study of Application of Ionic Liquid in Sample Pretreatment and Chemiluminescence in Chromatographic Analysis

Author: WuHongWei
Tutor: ZhuYan; ChenMeiLan
School: Zhejiang University
Course: Analytical Chemistry
Keywords: Ionic liquid (IL) sample pretreatment high performance liquidchromatography (HPLC) ion-exchange chromatography (IC) chemiluminescence(CL)
CLC: O657.7
Type: PhD thesis
Year: 2012
Downloads: 275
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In recent years, because of the complex matrix and low analyte content of sample of HPLC analysis, it is very important to develop new types of sample pretreatment methods and sensitive detection methods.In this work, the application of ionic liquid-based extraction techniques in sample pretreatment of different chromatographic methods was investigated. The combination of ion chromatography and chemiluminescence was also studied.Chapter one comprised a brief introduction of ionic liquid and its application in analytical chemistry and a comprehensive review of the application of ionic liquid extraction methods in sample pretreatment of chromatography. The information of chemiluminescence such as principle, apparatus structure, typical chemical luminescence system and combination of HPLC were summarized.In chapter two, a novel ionic liquid-based pressurized liquid extraction (IL-PLE) procedure coupled to high performance liquid chromatography (HPLC) tandem chemiluminescence (CL) detection capable of quantifying trace amounts of rutin and quercetin in four Chinese medicine plants was described. The effect of ILs with different cation on extraction efficiency was systematically investigated. In addition, the extraction performance of IL-PLE was compared with HRE and UAE for the extraction of rutin and quercetin in real samples. What is more, the selectivity of the proposed method was investigated by comparing the chromatograms of real sample obtained with CL detector and UV detector.In chapter three, the ionic liquid-based microwave-assisted dispersive microextraction (IL-based MADME) was firstly used to solid sample. The aim of this work is to simplify the analytical step, reduce the extraction time and improve the sensitivity. The effects of various experimental parameters were studied and the possible extraction mechanism was also discussed. The developed method was successfully applied to the analysis of real samples.In chapter four, a novel method was established for the simultaneous determination of resorcinol and phloroglucinol in environmental water samples by ion chromatography with chemiluminescence detection. The absence of methanol and acetonitrile in mobile phase made the proposed method more sensitive.In chapter five, without complicated derivative process and gradient elution, a simple, fast, sensitive, highly selective and eco-friendly analytical method for the determination of catecholamines in human urine was established originally in this paper, based on the combination technique of IC with the CL detection. Parameters related to IC separation and acidic potassium permanganate chemiluminescence system were optimized systematically.

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CLC: > Mathematical sciences and chemical > Chemistry > Analytical Chemistry > Instrument analysis ( physics and physical chemistry ) > Chromatographic analysis
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