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A Study on the Non-invasive Intervention to the Consistent Cervical Infection of Human Papillomavirus

Author: MengYaLi
Tutor: YueTianZuo
School: Tianjin Medical University
Course: Obstetrics and Gynaecology
Keywords: human papillomavirus cervical cancer CIN Rebacin high-risk type
CLC: R737.33
Type: Master's thesis
Year: 2012
Downloads: 51
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Abstract


Objective:This research through the use of Rebacin to do drug intervention therapy of Human Papillomavirus (HPV), Detection and observation of changes in patients with cervical HPV infection, combined with changes in indicators such as colposcopy, cytology and histology, and try to evaluate the efficiency and safety of non-invasive intervention therapy of sustained high-risk cervical human papillomavirus.Methods:60patients (21to58years old) with sustained high-risk cervical HPV infection in The Port of Tianjin Hospital gynecological outpatient department were picked, those colposcopy, biopsy does not meet the Class II cervical intraepithelial neoplasia (CINⅡ), Randomly divided into two groups:the experimental group of28patients and control group of32patients.Experimental group patients were given the Rebacin, vaginal administration every other day, use before bedtime continuously for three months except menstrual period; control group patients were not given any treatment and medication. Experimental group patients did follow ups after drug withdrawal and3months after the first follow up, the control group patients did follow ups3months later and6months later. All patients done general physical examination, blood routine, liver and kidney function, observed adverse reactions; at the same time, observed cervical appearance, done cervical thinprep cytologic test (TCT), detect cervical high-risk types HPV-DNA infection changes, colposcopy and cervical histology pathology.Results:1. cervical appearance:experimental group after treatment, the degree of cervical erosion index significantly decreased compared with those before treatment (P<0.05), while the control group had no significant change, the end of follow-up, two groups of patients with cervical appearance had significant difference (P<0.05);2. case with HPV infection:two groups at endpoint, HPV infection clearance efficiency comparison, the test group were higher than those in control group (P<0.05);3. two follow-up cervical cytology test in cervical cytology, group ASCUS and LISIL were decreased, but no significant difference between two groups (P>0.05);4. colposcopy Reid score:experimental group in the two follow-up, show a trend that decreased gradually with a diagnosis of colposcopy in Reid score than which before treatment, in the two follow-up, the statistical analysis display that the experimental group compared with those before treatment, there were significant differences (P<0.05), while in the control group, there were not statistical significance (P>0.05) within the three colposcopy Reid scores;5. histological examination:at the follow-up endpoint, two groups were detected by biopsy tip under the colposcopy, all cases didn’t d show higher grade intraepithelial neoplasia in development, and in the experimental group there were8cases showed a change that intraepithelial neoplasia disappeared, there was a statistically significant (P<0.05) within group comparisons; in the control group,2cases showed a change that intraepithelial neoplasia disappeared, but there was no statistical significance within group comparisons(P<0.05); compared the test group with control group after the treatment, in the test group, Consistent CIN I ratio is lower than the control group, but there wasn’t statistical significance (P>0.05).Conclusions:1. Use Rebacin to do treatment of sustained high-risk HPV infection has demonstrated noticeable effects of cleans the virus and improves cervical appearance;2. With the clearance of the virus the the colposcopy Reid score was significantly decreased, cytology and histology has also been improved;3. Adverse reactions were not observed. As a non-invasive intervention method, the use of Rebacin is an effective and safe way to treat sustained high-risk cervical HPV.

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CLC: > Medicine, health > Oncology > Genitourinary tumors > Female genital tumors > Uterine tumors
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