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Objective: detection of type 2 diabetic nephropathy in patients with serum levels of tumor necrosis factor-a (TNF-a), interleukin -18 (IL-18), lipid-linked prime (ADPN) and fasting blood glucose (FBG), glycosylated hemoglobin (HbAlc) urinary albumin excretion rate (UAER) and other related indicators to explore the relationship between type 2 diabetic nephropathy in patients with serum TNF-a, IL-18, the change of the ADPN level and influencing factors. Methods: random selection from October 2010 to February 2011 during treatment in Jilin University Sino-Japanese Friendship Hospital ward or confirm the diagnosis of T2DM patients with 50 cases, and in accordance with the urinary albumin excretion rate (UAER) divided into 2 groups: diabetes nephropathy (NDN group, 25 cases); 25 cases of diabetic nephropathy (DN Group). Select kidney disease, autoimmune disease, history of hypertension, diabetes and oral glucose tolerance test confirmed except outpatient physical examination in 25 cases, as normal control group (CTL group). All subjects detected TNF-a, IL-18, ADPN, FBG, HbAlc and JAER clinical indicators, indicators of differences between each group were compared, and TNF-a, IL-18, ADPN with other indicators related to analysis. Results: (1) the DN group NDN group with the CTL group sex, age, duration, body mass index constituted, the difference was statistically significant (P gt; 0.05), three sets of data are comparable. (2) DN group, the the NDN group of the FBG, HbA1c was significantly higher than the CTL group, the difference was statistically significant (P lt; 0.05); diabetic group, the DN group FBG, HbA1C slightly higher than the NDN group, but the difference was not statistically significant (P gt; 0.05) DN group UAER significantly higher than the the NDN group and CTL group, the difference was statistically significant (P lt; 0.01); the NDN group UAER slightly higher than the CTL group, but the difference was not statistically significant (P GT; 0.05) (3) the DN group NDN groups of TNF-alpha were significantly higher than the CTL group, the difference was statistically significant (P lt; 0.05); diabetic group, the DN group TNF-alpha was significantly higher than the NDN group The difference was statistically significant (P lt; 0.05). DN group, the the NDN group of IL-18 were significantly higher than the CTL group, the difference was statistically significant (P lt; 0.05); diabetic group comparison, the the DN group of IL-18 was significantly higher than the NDN group, the difference was statistically significant (P lt; 0.05). DN group ADPN significantly higher than the the NDN group and CIL group, the difference was statistically significant (P lt; 0.05); the NDN group of ADPN significantly lower than the CTL group, the difference was statistically significant (P lt; 0.05) (4) In patients with type 2 diabetes, serum TNF-alpha and FBG, HbAIC, UAER was significantly and positively related differences were statistically significant (P lt; 0.05, P lt; 0.01, P lt; 0.01); IL-18 with FBG HbAIC, UAER was a significant positive correlation, the differences were statistically significant (P values ??were lt; 0.01); ADPN the UAER showed a significant positive correlation (P lt; 0.01), and BMI, FBG, HbAIC was negatively correlated ( P values ??were lt; 0.05) Conclusions: (1) type 2 diabetic nephropathy in patients with serum TNF-alpha, IL-18, ADPN significantly higher than healthy people, and with an increase in UAER increased, suggesting that the inflammation involved in diabetic nephropathy, the development process. (2) The serum TNF-alpha, IL-18, ADPN level of lesions of diabetic nephropathy stage are closely related. (3) serum TNF-alpha, IL-18, ADPN level can be used as in patients with type 2 diabetes control glucose metabolism status is good or not one of the indicators. (4) in patients with type 2 diabetes, strict control of blood sugar, dynamic observation of serum TNF-alpha, IL-18, ADPN inflammation-related factors contributed to early detection and prevention of the occurrence and development of DN, reduce disability in patients with diabetes, death dangerous.
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