Dissertation > Excellent graduate degree dissertation topics show

Java Brucer Fruit Oil Emulsion on Ovarian Cancer Model Rat About MRP-1/CD9、Integrina5Mechanism of Experimental Study and Clinical Observation of Bu Shen Xiao Zheng Method

Author: ZhaoLiJun
Tutor: HanFengJuan
School: Heilongjiang University of Traditional Chinese Medicine
Course: Chinese Gynecology
Keywords: Java Brucea Fruit Oil Ovarian cancer Abdominal cavity for medicine Bu Shen Xiao Zheng method
CLC: R-332
Type: Master's thesis
Year: 2013
Downloads: 36
Quote: 0
Read: Download Dissertation

Abstract


Part1:Java Brucea Fruit Oil Emulsion Dosing On Model Rat Orthotopic Transplantation Tumor Tissue In Ovarian Cancer In The MRP-1/CD9And Int-egrina5Effect Of Experimental Research.Object:Observe the effect of Java brucea fruit oil emulsion abdom-ina dosing orthotopic nude mouse model of ovarian carcinoma tissues MRP-1/CD9and integrina5.Methods:Establish orthotopic transplantation tumor model of human ovarian cancer SKOV3cell lines nude mice.Randomly divided into4groups:Each group of eight,The blank group was given saline0.2ml each rat, Java brucea fruit oil emulsion group was given it0.2ml/20g, Cisplatin group given cisplatin3mg/kg0.2ml.C isplatin and joint grou-p given Java brucea fruit oil emulsion and Cisplatin group.Mice wer-e euthanized at dosing dislocated after6times of histopathological investigation, According to weight of tumors. Using immunohistochem-ical method to detect the expression of MRP-1/CD9and integrinα5. Result:1.Human ovarian cancer SKOV3cells in situ in nude mice t-ransplantation tumor model was established.2.The tumor control rat-eof Java brucea fruit oil is54%,Cisplatin group is66%, the joint gro-up is84%.3.Immunohistochemical results show:MRP-1/CD9and inte-grina5in the blank group Java brucea fruit oil group、cisplatin grou-p、and joint group expression from low to high respectively.Conclusion:Abdominal cavity to Java brucea fruit oil emulsion can provide prevention and treatment of invasion and metastasis of ovari-An cancer. It does not exclude the Java brucea fruit oil emulsion MRP-1/CD9and integrina5as targets for treatment of the possibility of o-varian cancer.Part2:Bu Shen Xiao Zhen Method of Clinical Observation of Improv-Ing the Quality of the Patients with Ovarian Cancer Survival. Object:Observe Bu Shen Xiao Zhen method for ovarian cancer patie-nts quality of life improved.Evaluation of this method under the gui-dance of traditional Chinese medicine prescription Li Chong Sheng Sui Yin the clinical function of patients with ovarian cancer.Methods:30patients who meet eligibility criteria were selected with postoperative chemotherapy for ovarian cancer.Mainly Uses Li Chong Sheng Sui Yin,add and subtract with clinical syndrome.Oral Chinese herbal medicine medicinal broth for3months,Curative effect were o-bserved before and after treatment of TCM syndrome score、Kupperm-an Index、QOL, results anlyzed using statistical software.Result:1、Bu Shen Xiao Zhen method of treatment of kidney and b-lood stasis type of ovarian cancer clinical total effective rate was83%,greatly improve the effective rate of33%of syndromes. After treatment Kupperman Index has been down and QOL improved,the dif-ference has statistical significance.Conclusion:Bu Shen Xiao Zheng method can improve the shape of sy-ndrome、Kupperman Index、QOLof the patients with ovarian cancer. No adverse reaction, non-toxic side effects of safety and feasibility.

Related Dissertations

  1. Expression and Their Significance of Apoptosis Regulatory Factors Survivin、XIAP and c-Jun、NF-κB in Epithelial Neoplasm of Ovary,R737.31
  2. Effects on Telomere Length of Epithelial Ovarian Cancer by Chemotherapy,R737.31
  3. Recurrent Ovarian Cancer Surgery Again with Surial Analysis of Relevant Factors,R737.31
  4. Surveys of Short-term Efficacy of TP Therapeutic Regimen Applied to 81 Cases of Ovarian Cancer Patients,R737.31
  5. Expressions and Relationships of PI3K/AKT and Apoptosis Related Regulation Factors in Epithelial Ovarian Tumors,R737.31
  6. Anti-tumor Effect of Trastuzumab on Nude Mice Xenografts of Human Ovarian Cancer SKOV3 Cells and Its Synergistic Effect of Action with Docetaxel, Cisplatin,R737.31
  7. The Influence and Mechanisms of Mythylglyoxal on Growth and Apoptosis of Human Ovarian Cancer Cells HO8910,R737.31
  8. A Clinical Investigation of the Diagnostic Value of Ovarian Cancer by the Combination of Osteopontion and Lysophosphatidic Acid,R737.31
  9. The Significance of EGFR and STAT3 mRNA Expression in Epithelial Ovarian Cancer,R737.31
  10. Isolation and Identification of Tumor Stem Cells from Human Ovarian Carcinoma Cell Line A2780,R737.31
  11. Transforming growth factor β1 (TGF-β1) and its receptor TβR-Ⅰ, TβR-Ⅱ expression in epithelial ovarian cancer,R737.31
  12. The Relativity between Expressions of Cyclin A and P27 in Ovarian Cancer,R737.31
  13. Artificial intelligence -based prognostic models of epithelial ovarian cancer research,R737.31
  14. MicroRNA-21 and -141 in patients with epithelial ovarian cancer tissue and serum Expression and Clinical Significance,R737.31
  15. The Expression of Stathmin in Ovarian Cancer and the Effect on Chemosensitivity to Cisplatin in Ovarian Cancer Cells,R737.31
  16. Smilax China L. Rhizome Extracts Exerts Potent Activity Against Ovarian Cancer Cells and Their Mechanisms,R737.31
  17. To Seek the Different Proteins in Ovarian Cancer Cells by Two-dimensional Electrophoresis,R737.31
  18. Inhibition of CD24 Expression to Induce Anoikis in Ovarian Cancer Cells,R737.31
  19. Expression and Clinical Significance of Fatty Acid Synthase in Ovarian Cancer,R737.31
  20. Effects of Apigenin on Trail-induced Apoptosis in Human Ovarian Cancer CoC1 Cells,R737.31
  21. Clinical Analysis of 52 Recurrent Ovarian Cancer Patients,R737.31

CLC: > Medicine, health > Medical research methods > Experimental medicine, medical experiments > Medical Laboratory Animal Science
© 2012 www.DissertationTopic.Net  Mobile