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Movement in spontaneously hypertensive rat ANP and NPR - A mRNA expression and the mechanism of action

Author: ZhaoShuYing
Tutor: ZhangJun
School: Yangzhou University
Course: Human Movement Science
Keywords: Hypertension Movement Atrial natriuretic peptide Natriuretic peptide receptor A Angiotensin II Cyclic guanosine monophosphate
CLC: G804.2
Type: Master's thesis
Year: 2010
Downloads: 59
Quote: 1
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Abstract


Objective: To observe the movement of the spontaneously hypertensive rat plasma and myocardial content of ANP, cardiac and renal NPR-A mRNA expression in suitable exercise on the prevention of hypertension and its complications and its mechanism of hypertension and its prevention of complications provide a theoretical basis. Methods: 16 male Wistar rats were randomly divided into sedentary control group (WC group) and exercise group (WT group), 16 male SHR rats were randomly divided into sedentary control group (SC group) and exercise group (ST group ), n = 8. WT and ST group without load for 60 minutes a day swimming, six times a week for 8 weeks. Weekly during the experimental determination of blood pressure and body weight were measured after 8 weeks the rats heart coefficient plasma and myocardium ANP content, cardiac and renal NPR-A mRNA expression, plasma and myocardial Ang II content, cardiac and kidney cGMP content and other indicators . Results: 1.8 weeks after the experiment, the blood pressure of SHR quiet group than before the experiment was significantly higher (P lt; 0.01), SHR exercise group compared with blood pressure before the experiment increased, but no significant difference (P gt; 0.05), SHR The blood pressure of the exercise group compared with SHR quiet rats blood pressure decreased significantly (P lt; 0.01). Exercise can delay the SHR rats increased blood pressure. The quiet body weight of rats of the Wistar exercise group compared with Wistar rats body weight decreased significantly (P lt; 0.01), body weight of rats SHR SHR exercise group quiet group body weight of rats decreased significantly (P lt; 0.01),. Exercise can reduce the weight of Wistar rats and SHR rats. 2.8 weeks after the experiment, the coefficient of rat heart of the the SHR quiet group was significantly higher than quiet Wistar rats (P lt; 0.01) and Wistar exercise group (P lt; 0.05), high blood pressure can cause heart increased by a factor. The exercise group of Wistar rat hearts coefficient was significantly higher than the quiet group of Wistar rats (P lt; 0.05), the exercise can be increased coefficient of normal rat heart. SHR exercise group coefficient of rat heart was significantly lower than the the SHR quiet rats (P lt; 0.05), exercise can lower the coefficient of hypertensive rat heart. 3.8 weeks after the experiment, the the SHR quiet rats and SHR exercise group rat plasma ANP in Wistar quiet rats was significantly higher (P lt; 0.01), hypertension lead to an increase in plasma ANP levels. SHR exercise group plasma ANP in SHR quiet rats increased, but no significant difference (P GT; 0.05), the movement does not significantly higher in hypertensive rats plasma levels of ANP. SHR quiet rats and SHR exercise group rat plasma Ang Ⅱ content Wistar quiet rats was significantly higher (P lt; 0.01) hypertensive rat plasma AngII content was significantly higher. Wistar exercise group compared with Wistar rat plasma concentration of Ang Ⅱ quiet rats increased, but there was no significant difference (P gt; 0.05), SHR SHR exercise group plasma concentration of Ang Ⅱ quiet rats has decreased, but no significant difference (P gt; 0.05), the movement had no significant effect on normal rats and hypertensive rats plasma Ang II level. 4.8 weeks after the experiment, the the Wistar movement in myocardial ANP in Wistar quiet rats was significantly higher (P lt; 0.01), the movement can be increased ANP levels in the normal rat myocardium. Quiet SHR movement in myocardial ANP in SHR rats, although increased, but no significant difference (P gt; 0.05) SHR quiet rats and SHR exercise group rat myocardial Ang II content compared with Wistar quiet rats was significantly higher (P lt; 0.01), hypertensive rats Ang II was significantly higher than in normal rats. Rats compared with SHR quiet, SHR movement in myocardial Ang II content SHR quiet group rats were significantly lower (P lt; 0.01), exercise can reduce hypertensive rats Ang Ⅱ level. 5.8 weeks after the experiment, the the Wistar movement in myocardial NPR-A mRNA expression compared with quiet Wistar rats was significantly higher (P lt; 0.05), SHR exercise group the rat myocardium NPR-A mRNA expression compared with SHR quiet rats increased (P lt; 0.01), increased movement of normal rats and rats with hypertension myocardial NPR-A mRNA expression levels. SHR exercise group the rat kidneys NPR-A mRNA expression than SHR quiet rats was significantly higher (P lt; 0.05). Movement can be increased hypertensive rat kidney NPR-A mRNA expression levels. Conclusion: a suitable long-term regular exercise can significantly inhibit the further increase of SHR, blood pressure, high blood pressure have a certain role in mitigation, while the growth of the movement Wistar rats and SHR rat body weight have some effect. 2 the results of this experiment show that ANP and NPR-A plays an important role in the the movement prevention and treatment of hypertension and heart damage. The possible mechanism: long time regular appropriate exercise can be increased in myocardium and kidney of ANP receptor NPR-A mRNA expression level in conjunction with the ANP increased hypertensive rats and kidney the level of messenger-cGMP, which play the role of ANP lowering blood pressure and myocardial cell hypertrophy and proliferation, antagonistic role of Ang II in the boost and promote cardiac hypertrophy.

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