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Studies on the Chemical Constituents of Ammopiptanthus

Author: FengWenJuan
Tutor: LiJin
School: Xinjiang Normal University
Course: Botany
Keywords: Ammopiptanthus mongolicus Ammopiptanthus nanus Chemical constituents Ammopiptanoside A
CLC: R284
Type: Master's thesis
Year: 2011
Downloads: 66
Quote: 0
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Abstract


The genus Ammopiptanthus, a survivor of the evergreen broadleaf shrub in the central Asia desert from the Tertiary period, it belongs to the tribe Thermopsideae of the Leguminosae. Ammopiptanthus comprises two species, the one is Ammopiptanthus mongolicus (Maxim.) Cheng f., which is widely distributed in Mongolia, Ningxia and Gansu; the other is Ammopiptanthus nanus (Popov.) Cheng f., which is mainly distributed in Kizilsu Autonomous Prefecture in the southwest of Xinjiang province and neighboring central Asia.The aerial parts of Ammopiptanthus has been used as a folk medicine for the treatment of cough, congelation and chronic rheumatic arthritis, etc. Alkaloids and flavonoids are the characteristic chemical constituents of Ammopiptanthus, according to the literature.The alcohol extracts of A. mongolicus and A. nanus showed significant hypoglycemic effect in the research of anti-diabetes drug selecting. In order to search for the hypoglycemic pricinples and to establish a foundation for researching and developing drugs that can prevent and cure diabetes, our work focused on the chemical constituents of Ammopiptanthus. Isolation and purification were carried out by various column chromatographic methods. The structures were elucidated on the basis of spectroscopic analysis and chemical methods as well.In this thesis, 12 compounds were abtained from the twigs of A. mongolicus alcohol extracts, including 6 isoflavonoids: formononetin (1), ononin(2), isolupalb- igenin (3), daidzein 4′,7-di-O-β-D-glucoside (4), glycitein-4′, 7-di-O-β-D-glucoside (5), genistein 4′,7-di-O-β-D-glucoside(6); 1 derivate of flavonoid: (+)-maackiain (7); 1 phenols: brevifolin (8); 1 diolefine: triacontane (9); 2 sterols:β-sitosterol (10),β-dauco -sterol(11); 1 cyclitol: sequoyitol(12); Among them, compound 5 is a new compound, named as Ammopiptanoside A, and compound 3、4、6、8、9、12 were isolated from the plants of this genus for the first time. 13compounds were isolated from the leaves of A. nanus alcohol extracts and 6 were determined, including 3 isoflavonoids: ononin(1)、daidzein4′,7-di-O-β-D-glucoside(2)、genistein4′,7-di-O-β-D-glucoside (3); 1benzoic acid glycoside: 4-O-β-D-glueopy ranosyloxy-benzoic acid (4); 1 phenylprop- anoid: syringin(5);1 cyclitol: sequoyitol(6); the above 6 compounds were isolated form A. nanus for the first time. A. mongolicus and A. nanus with high similarity in chemical constituents, and the contents of alkaloids in leaves of the two species are much more than twigs, which based on the TLC、LC-MS analysis.Some of the compounds abtained from the plants of Ammopiptanthus showed bioactivities according to the documents: sequoyitol showed significant hypoglycemic effect, formononetin have an eminent hypolipidemic effect, ononin with bioactivities of antioxidant, maackiain showed excellent anti-inflammation and anti-tumor activity, brevifolin can protect hepar from acute and chronic injury, syringin is used for stoping bleeding and hepatic detoxing.

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