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Objective To construct the scoring model of liver cirrhosis disease(SLCD), to find a new score formula which was the SLCD score formula for the liver impairment and function reserve with the Matter-Element Analysis method.Methods To construct the rat liver cirrhosis model of experimental rat with composite factor method. In different phases of the rat liver cirrhosis model, to give a serological detection to the dynamic changes of liver impairment degree and liver function reserve, and a histological observation to the liver pathological alteration. To obtain the SLCD score formula by using the Matter-Element Analysis method.Results The experimental rat liver cirrhosis model was successfully copied. The experimental rat SLCD and SLCD score formula were successfully constructed with six detection indexes which were weeks, TBil, Alb, PA, PT-INR, SCr. The score was expressed by R, with the pathological changes and fibrosis were aggregated, R was gradually decreased. R=1, it meant the liver tissue was normal; 0.702≤R<1, it meant there were inflammatory reaction, focal degeneration and necrosis in liver; 0.542≤R<0.702, it meant there was fibroplasia in liver; 0.352≤R<0.542, pseudolobules were formed and it was in the liver cirrhosis stage. R﹤0.352, it meant later stage of liver cirrhosis.Conclusions The SLCD score formula was comparatively sensitive and exact in reflecting the liver impairment and liver function reserve of the experimental rat liver cirrhosis, if there would be clinical evidence on the application value, then it may be helpful for the early clinical prevention, diagnosis and treatment for the cirrhosis disease.
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