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Expression and Implication of P16,CyclinD1 and CDK4 in Colonic Carcinoma

Author: JiangZuo
Tutor: QuanChengShi；GeHua
School: Jilin University
Course: Pathology and Pathophysiology
Keywords: Colorectal cancer P16 CyclinD1 CDK4
CLC: R735.34
Type: Master's thesis
Year: 2011
Downloads: 41
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Abstract


Objective: In this study, using SP immunohistochemical staining methods , detection of P16 of CyclinD1 and CDK4 expression in colorectal cancer , and to analyze the relationship with colorectal cancer clinical indicators and their significance . Methods: SP immunohistochemical staining methods for 60 cases of colorectal carcinoma and 60 cases of corresponding adjacent tissues P16 , CyclinD1 and CDK4 detection and analysis of clinical indicators . Results: The experimental results show that the P16 expression in colorectal cancer tissues were significantly lower than the adjacent tissues , associated with Duke s stage and degree of differentiation (P lt; 0.05); CDK4 expression in colorectal cancer was significantly higher than paraneoplastic organization , CDK4 expression in the Duke s staging high and low degree of differentiation of cancer tissue was significantly higher (P lt; 0.05); colorectal cancer tissue CyclinD1 positive rate was significantly higher than the adjacent tissues , and with Duke's staging high and low degree of differentiation , and the expression of CyclinD1 expression was significantly increased (P lt; 0.05); colorectal carcinoma P16, CyclinD1 and the CDK4 expression of CDK4 in colorectal cancer tissue correlation analysis showed a positive correlation with CyclinD1 . Conclusion: colorectal carcinoma downregulation of P16 and CyclinD1 and CDK4 upregulation of play an important role in the development of colorectal carcinogenesis , and can serve as indicators determine the degree of malignancy of colorectal .

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CLC: > Medicine, health > Oncology > Gastrointestinal Cancer > Intestinal neoplasms > Colorectal tumors
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