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Objective: To investigate the non-alcoholic fatty liver disease and coronary heart disease relationship, possible mechanisms and ALT in which the possible role and significance. Method: observation group were a total of 105 cases were hospitalized with fatty liver of Chinese Medical Association the hepatology credits will learn group from February 2009 to February 2011, the Sino-Japanese Friendship Hospital, \\49 cases, 46 cases of women aged between 35-65 years old, with an average of (50.4 ± 10.4) years. Serum ALT levels observed group was divided into two sub-groups: A (ALT> 40IU / L) 50 Li; B group (ALT <40IU / L) 55. Application of U.S. BECKMAN SYNCHRON LX20 automatic biochemical analyzer using immune turbidimetric method all selected personnel of serum total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), serum apolipoprotein A1 (Apo A1), apolipoprotein B (Apo B), serum alanine aminotransferase (ALT), blood uric acid (UA), fasting glucose (GLU) and Calculate Apo A1 / Apo B values. Application American GE company vivid7, Color Doppler ultrasound detected in patients with carotid artery intima-media thickness (IMT). In results: ① observation group and the control group, the level of serum TC, TG, LDL-C was significantly higher than the normal control group, the difference was significant (P lt; 0.05); HDL-C levels below the normal control group, a significant difference (P lt; 0.05); A group and B group, TC, TG, LDL-C, Apo B levels tended to increase HDL-C, Apo A1 level, Apo A1 / Apo B value compared to the decline, but the difference was not statistically significant (P gt; 0.05). ② ALT levels and TG levels were positively correlated (r = 0.166, P lt; 0.05). (3) observation group compared with the control group, fasting GLU levels were significantly higher than the normal control group, the difference was significant (P lt; 0.05); A group and B group, fasting GLU increased, but no statistical difference significance (P gt ; 0.05). (4) observation group compared with the control group, serum uric acid was significantly higher than the normal control group, a statistically significant (P lt; 0.01); A group and B group, the blood uric acid level is higher than group B, a significant difference (P lt; 0.01 ). (5) the observation group compared with the control group, IMT: group A (1.27 ± 0.06) mm in group B (0.75 ± 0.03) mm, the control group (0.29 ± 0.03) mm, were significantly different (P lt; 0.05); neck The number of arterial plaque: A group (2.23 ± 1.35), B group (1.67 ± 1.42), the control group (1.30 ± 1.56), were statistically significant (P lt; 0.05); carotid plaque detection rate of group A : 79.2%, B group: 68.4%, control group 55.4%, There was a significant difference (P lt; 0.05). Group A compared with group B, IMT: group A (1.27 ± 0.06) mm, group B (0.75 ± 0.03) mm, the difference was significantly (P lt; 0.05); number of carotid artery plaque: A group (2.23 ± 1.35) group B (1.67 ± 1.42) was statistically significant (P lt; 0.05); carotid plaque detection rate in group A: 79.2%, group B: 68.4%, a significant difference (P lt; 0.05). Conclusion: ① non-alcoholic fatty liver incidence of coronary heart disease in patients with significantly elevated serum ALT levels. ② ALT levels and the severity of coronary heart disease. ③ trigger the possible mechanisms of lipid metabolism disorders, hyperuricemia, hyperglycemia and other risk factors for atherosclerosis. ④ non-alcoholic fatty liver disease may be an independent risk factor for coronary heart disease.
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