Dissertation > Excellent graduate degree dissertation topics show

Association of Interleukin-6 Gene Polymorphisms with Susceptibility to Coronary Heart Disease in Asian Populations: a Meta-analysis

Author: GaoMin
Tutor: YeDongQing
School: Anhui Medical University,
Course: Public Health and Preventive Medicine
Keywords: Interleukin-6 Gene polymorphism Coronary heart disease Meta-analysis
CLC: R541.4
Type: Master's thesis
Year: 2011
Downloads: 18
Quote: 0
Read: Download Dissertation


ObjectivesTo quantitatively summarize the association of interleukin-6 gene polymorphisms with coronary heart disease using meta-analysis in Asian populations.MethodsWe surveyed studies on the association of interleukin-6 gene polymorphisms with coronary heart disease in Pubmed, Elsevier Science Direct, Cochrane Library, Chinese Biomedical Literature Database, Wanfang and China National Knowledge Infrastructure. All articles were strictly evaluated and screened according to inclusion criteria, and meta-analysis were perfomed for the included studies using RevMan 4.2 software.ResultsWe identified 11 studies (1821 cases and 2453 controls) using search. Of eligible studies, 8 studies were conducted in Chinese, 1 studies were conducted in Korean, 1 studies were conducted in Japanese, 1 studies were conducted in Indian. Meta-analysis was performed for three interleukin-6 gene polymorphisms (-572C/G,-174G/C, and -634C/G). Significant association was seen for -572C/G polymorphism (G vs C: OR=1.48, 95%CI=1.21-1.82, P=0.0002; CG+GG vs CC: OR=1.57, 95%CI=1.33-1.86, P<0.00001; GG vs CC+CG: OR=1.82, 95%CI=1.23-2.68, P<0.003; GG vs CC: OR=2.01, 95%CI=1.34-2.99, P=0.0007; CG vs CC: OR=1.51, 95%CI=1.27-1.79, P<0.00001) and -634C/G polymorphism (G vs C: OR=1.25, 95%CI=1.04-1.49, P=0.01; CG+GG vs CC: OR=1.14, 95%CI=0.92-1.41, P=0.24; GG vs CC+CG: OR=2.30, 95%CI=1.48-3.56, P=0.0002; GG vs CC: OR=2.23, 95%CI=1.44-3.48, P=0.0004; CG vs CC: OR=1.02, 95%CI=0.82-1.29, P=0.83) in interleukin-6 gene, but not for -174G/C polymorphism (C vs G: OR=0.92, 95%CI=0.64-1.32, P=0.65; GC+CC vs GG: OR=0.82, 95%CI=0.55-1.22, P=0.33; GC vs GG: OR=0.74, 95%CI=0.49-1.13, P=0.17).ConclusionsThis meta-analysis demonstrates that coronary heart disease is associated with interleukin-6 gene -572C/G and -634C/G polymorphisms in Asian populations, but not -174G/C.

Related Dissertations

  1. CYP2C19 Gene Polymorphism in Patients with Ischemic Cerebrovascular,R743
  2. The Preliminary Study on Interleukin-10 Transgenic Mice,Q78
  3. Methodology for Linkage-map-based Quantitative Trait Loci Synthesis Analysis,S562
  4. Study on the Expression and Bioactivities of Porcine Interleukin-2/6 Fusion Protein in Vivo and in Vitro,S858.28
  5. The Relationship of Polymorphisms of Methionine Synthase Reductase(MTRR) Gene and Plasma Homocysteine Levels with Myocardial Infarction,R542.22
  6. The Influence in Different Route of Medication with Vitamin A on CD4~+CD25~+ Regulatory T Cell and Cell Factor of IL-4、 IFN-γ in a Rat Persistent Asthma Model,R562.25
  7. Observastion on Histomorphology, Ultrastructure and Expression of TNF-α, IL-1β of Unbalance of Dynamic and Static Forces Cervical Degeneration Disc in Rat Model Abstract,R681.55
  8. Dual-source CT in the Diagnosis of Coronary Artery Stenosis: a Meta Analysis,R541.4
  9. Improvement of Interleukin Profiles in Patients with Type 2 Diabetes Mellitus After Add-on Acarbose Therapy Independent of Glycemic Control,R587.1
  10. Malignant Transformation of Ovarian Endometriosis-related Protein Expression in the Meta-Analysis,R711.71
  11. Effects on Recombinant Human Interleukin-10 of IL-2, IFN-γ, GCs, T Cell Apoptosis in Transplantation of the Rabbit Skin,R392
  12. Heterogeneity and Meta Analysis of the Essential Hypertension Risk Assessments,R544.1
  13. Correlation Analysis between Coronary Lesion Severity and Peripheral Blood Cell CD34~+ Ratio in the Coronary Heart Disease Patients Complicating Diabetes Mellitus,R541.4
  14. Study on the Correlation Between the Levels of Il-18, IL-33 and Other Inflammatory Factors and Pulmonary Function in Different Stages of Asthma,R562.25
  15. Effects of Health Education Managment on the Asthma Control: Meta-analysis,R562.25
  16. Study on the Correlation btween Serum, Aqueous Humor VEGF, IL-6 Levels and the Neovascular Glaucoma,R775
  17. Study of the Expression of Toll-like Receptor 2, 4mRNA and Polymorphisms of Patients with Leprosy,R755
  18. MDR1 and CYP3A gene polymorphisms on digoxin plasma concentrations of,R96
  19. Restructuring Agkistrodon disintegrin Adinbitor human non-small cell lung cancer cell line A549,R285.5
  20. MPO, IL-18 and INF-γ expression in human coronary arteries with plaque stability and preliminary study,R541.4

CLC: > Medicine, health > Internal Medicine > Heart, blood vessels ( circulatory ) disease > Heart disease > Coronary arteries ( atherosclerosis ),heart disease (CHD)
© 2012 www.DissertationTopic.Net  Mobile