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The Clinical Significance of HIF-1α, CA IX and GLUT-1 Expression in Nasopharyngeal Carcinoma

Author: WuShiHai
Tutor: LiXianMing
School: Jinan University
Course: Oncology
Keywords: Nasopharyngeal Hypoxia inducible factor 1α (HIF-1α) Carbonic anhydrase Ⅸ (CA Ⅸ) Glucose transporter (GLUT-1) Immunohistochemistry
CLC: R739.63
Type: Master's thesis
Year: 2011
Downloads: 28
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Abstract


Objective To study the nasopharyngeal tissue hypoxia inducible factor la (HIF-1α), carbonic anhydrase IX (CA Ⅸ) and glucose transporter 1 (GLUT-1) expression and nasopharyngeal carcinoma biological behavior and prognosis between investigate the relationship between HIF-1α, CA IX and GLUT-1 protein in nasopharyngeal carcinoma diagnosis, staging, treatment and prognosis of the role. Using immunohistochemistry to detect the expression of the the NPC biopsies 2007-2011 collected 134 cases and 20 cases of nasopharyngeal chronic inflammation organization of HIF-1α, CA IX and GLUT-1 protein and HIF-1α CA Ⅸ and GLUT-1 expression with clinicopathological parameters and prognosis in nasopharyngeal carcinoma. Results The positive expression rate of HIF-1α protein in nasopharyngeal carcinoma and the nasopharynx chronic inflammation organization were 51.5% and 0%, respectively, and the difference was statistically significant (P lt; 0.05); HIF-age ≥ 50 age group 1α expression was significantly higher than the age lt; 50-year-old group, the expression of HIF-1α-positive lymph node metastasis group was significantly higher than the group of non-cervical lymph node metastasis, advanced (III and Ⅳ) the nasopharyngeal group of HIF-1α positive expression higher than early (I and Phase Ⅱ) NPC group inspected the three groups differences were statistically significant (P lt; 0.05). Overall survival (OS) in patients with positive expression of HIF-1α trend lower than those with negative expression (P = 0.055), positive expression group of NPC patients disease-free progression-free survival (PFS) was significantly lower than the negative expression group ( P = 0.014). Nasopharyngeal tissue and nasopharyngeal chronic inflammatory tissue the CAIX protein positive expression rate of 54.5% and 15%, and the difference was statistically significant (P lt; 0.05). CA Ⅸ positive expression correlated with sex, age, T stage, neck lymph node status and clinical stage no significant sex (P gt; 0.05). CA IX positive expression group patients with nasopharyngeal carcinoma disease progression-free survival (PFS) was significantly lower than the negative expression group (P = 0.008), while the difference between the two groups of patients overall survival (OS) was not statistically significant (P = 0.150 ). In nasopharyngeal carcinoma, nasopharyngeal chronic inflammatory tissue GLUT-1 protein expression rate were 50% and 10%, respectively, the two groups have a significant difference (P lt; 0.01). Age ≥ 50 years GLUT-1 positive expression rate was significantly higher than the age lt; 50-year-old group (P lt; 0.05), and GLUT-1 expression was correlated with patients' gender, T stage, cervical lymph node status and clinical stage no significant correlation. GLUT-1 positive expression group of NPC patients disease progression-free survival (PFS) was significantly lower than the negative expression group (P = 0.024), while the patients overall survival (OS) between the two groups the difference was not statistically significant (P = 0.078). GLUT-1 protein expression of HIF-1α and CA Ⅸ protein in nasopharyngeal carcinoma showed no obvious correlation; expression of HIF-1α and CA Ⅸ protein in nasopharyngeal carcinoma correlation (r = 0.282, P = 0.01) Conclusion of HIF-1αCAIX and GLUT-1 protein expression in nasopharyngeal carcinoma showed that HIF-1α, CAIX and GLUT-1 may be involved in the pathogenesis of nasopharyngeal carcinoma and development process are; HIF-1α protein-positive expression in nasopharyngeal cancer diagnosis and staging of a certain value; nasopharyngeal carcinoma HIF-1α, CA IX and GLUT-1 protein positive expression in patients with poor prognosis; joint, directly or indirectly, against hypoxic channel targeted therapy possible can benefit patients with nasopharyngeal carcinoma.

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CLC: > Medicine, health > Oncology > Department of Otolaryngology tumor > Pharyngeal tumors
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