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The Research on Clinical Application of Precise Radiotherapy in Gastric Cancer

Author: YangZhengQiang
Tutor: YuZuoHua
School: Jinan University
Course: Oncology
Keywords: Gastric cancer Radiotherapy Organ motion Breathe freely Active Breathing Control Fractionated radiotherapy to move between
CLC: R735.2
Type: Master's thesis
Year: 2011
Downloads: 33
Quote: 0
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Abstract


The aim of the present study in gastric cancer radiotherapy with active breathing control the technical ( ABC ) , the movement of the markers of gastric cancer radiotherapy target volume analysis to guide the development of the safety of the putting boundaries in gastric cancer radiotherapy to improve the accuracy of the gastric cancer radiotherapy . Methods 20 gastric cancer patients after surgery , placed in the tumor bed or lymph nodes draining silver clip as a marker , postoperative three-dimensional conformal radiotherapy accurately . With the to radiotherapy same position , weekly, free-breathing phase 0 ° and 90 ° target image acquisition simulator 20 each , the same method , 20 each of 0 ° and 90 ° target image acquisition in active breathing control . Application NIH Image J image processing software processing of the obtained image . Measurement breathe freely and application of ABC silver range of movement in three directions on the head and feet , back and forth and around , including a range of movement between fractionated radiotherapy and fractionated radiotherapy ; mobile ABC control breathing after the target . The target moving average breathe freely state in the head feet or so before and after the three directions were 12mm, 2.2mm , 5.0mm ( F = 86.35 , P = 0.000 ) ; spontaneous breathing control ABC , the first feet , or so , the average mobility before and after three directions were 2.4mm l.2mm 1.9mm (F = 18.76 , P = 0.000 ) . Active breathing control ABC , head and feet , or so , and before and after three directions on the target mobile breathe freely state compared to significant decrease in the head and feet and the front and rear direction ( t = 4.35 , P = 0.000 ; t = 3.75, P = 0.000), while in the left and right directions were no significant differences ( p gt ; 0.05) . Points radiotherapy target volume mobile application active breathing control mobile computing cluster center silver clip , head and feet, or so, before and after the three mobile direction for 2.8mm , 1.6mm , 2.7 mm ( F = 4.05 , P = 0.018 ) . Conclusions in gastric cancer radiotherapy target moving mainly caused by respiratory movement , quiet breathing state , target movement in the direction of the head and feet , left and right direction minimum . Therefore , when setting the PTV boundary should pay attention to the different direction to expand outside the border should be treated differently . Using the active breathing control techniques ABC , moving target in the head and feet and the front and rear direction were significantly reduced. Fractionated radiotherapy , radiotherapy target volume of mobile also need attention .

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CLC: > Medicine, health > Oncology > Gastrointestinal Cancer > Gastric neoplasms
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