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Association between Polymorphisms of ERCC1 and Response in Patients with Advanced Non-small Cell Lung Cancer Receiving Platinum-based Chemotherapy

Author: ChengJian
Tutor: HaMinWen
School: Liaoning Medical
Course: Oncology
Keywords: Non-small cell lung carcinoma Platinum-based Chemotherapy ERCC1 Polymorphism
CLC: R734.2
Type: Master's thesis
Year: 2011
Downloads: 56
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Abstract


ObjectiveBy detecting non-small cell lung cancer ERCC1(C118T) gene polymorphism, to analyze its clinical characteristics and sensitivity to platinum-based chemotherapy relationship between genetic indicators for the determination of clinica chemotherapy drugs, for individual treatment and lay the foundation for improved chemotherapy.MethodApplications with real-time fluorescent PCR probe AllgloTM detected in January 2007-2008 in May during the First Affiliated Hospital of Liaoning Medical University Department of Oncology, confirmed by cytology or histology of 142 patients with untreated advanced NSCLC patients with ERCC1 Asnl18Asn(C→T,rsl1615)polymorphism, the patients were classified genotype, comparing the relationship between genotype and chemosensitivity, and conducted follow-up study ERCC1 Asnl18Asn with different genotypes and survival after platinum chemotherapy (1,2-year survival rate, Median OS, median PFS) relationship.Results(1) ERCC1 codon 118 genotype frequencies were C/C 60.6% (86/142), C/T 33.1% (47/142) ,T/T 6.3% (9/142);(2) ERCC1 118 locus was correlated with the curative effect(P﹤0.05), C118T locus for the C/C short-term remission (39.5%) was significantly higher than that of genotype C/T or T/T patients (21.4%)(P﹤0.05), but the degree of differentiation with NSCLC, sex, agepathological type of independent, (P﹤0.05), the difference was not statistically significant;(3) gender, age, PS score of three factors on progression-free survival time were not significantly affected, stage of cancer patients,differentiation,and C118T were closely related with the PFS. C118T locus for the C/T or T/T is a risk of disease progression in patients with C/C genotype was 1.870 times that of patients (P<0.001);(4) carrying ERCC1 codon 118 C/C genotype of chemotherapy sensitivity C/T and T/T genotype carriers of 2.041 times. (95% CI, 1.065-3.910, P=0.032); ERCC1 118 C/C genotype in patients with C/T and T/T genotype of the median PFS was significantly different (5.8 months vs 5.4 months, P=0.032);(5) C/C genotype overall survival (overall survival, OS) higher than the C/T and T/T genotype (8.2 months vs 7.2 months, P<0.001).Conclusions(1) ERCC1 118 polymorphism may be associated with advanced non-small cell lung cancer chemotherapy in patients with platinum-correlation for advanced non-small cell lung cancer and provide experimental basis for individual treatment;(2) Through clinical follow-depth study of survival and other indicators, ERCC1 118 C/C genotype compared with individual patient chemosensitivity C/T or T/T genotype in patients with high; CC gene The median PFS of patients With type and OS compared with C/T or T/T genotype patients live longer, suggesting that ERCC1 118 polymorphism was associated with PFS and OS, ERCC1 118 polymorphism can be used in patients with advanced non-small cell lung cancer chemotherapy in platinum-sensitive factor;(3) by Cox regression analysis, suggesting that poorly differentiated, poorly differentiated and C118T locus for the C/T or T/T may be early disease progression factor,ERCC1 118 polymorphism is PFS in patients with advanced NSCLC independent factors.

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CLC: > Medicine, health > Oncology > Respiratory system tumors > Lung tumors
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