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Objective: viral hepatitis, especially hepatitis B and its complications, is a serious threat to human health diseases. Given that the disease has still lacks effective treatment, diagnosis and treatment in Chinese medicine and the characteristics of the overall concept, as well as disease prevention and individual overall combined treatment modalities in the prevention and treatment of hepatitis B has shown a strong advantage, years of research and practical results show that in China, Chinese medicine prevention of viral hepatitis, cirrhosis and other liver diseases other therapies have become an irreplaceable important ways and means, thus enhancing Chinese medicine treatment of this disease research, promote Chinese characteristics, to explore Chinese medicine diagnosis and treatment of this disease law, opening up an effective therapeutic approach to the protection of people's health is important. In this study, the principle component Jianpihuoxuetongluo Jianpihuoxuetongluo square, comparative law and Jianpihuoxuetongluo adefovir dipivoxil for hepatitis B e antigen-negative chronic treatment, exploring e antigen-negative chronic hepatitis B is more effective, more economical treatment. Methods: 60 patients were observed from the Guangzhou University of Chinese Medicine, First Affiliated Hospital of January 2008 - October 2008 Section outpatient parenteral hepatitis, select compliant patients with chronic hepatitis B were randomly divided into three groups, ie Jianpihuoxuetongluo party group of 20 cases, 19 cases of adefovir dipivoxil group and combined treatment group 21 cases, and were before treatment and after 3 months, 6 months after the detection of each group of ALT, AST, viral DNA quantitative (HBV-DNA), before and after treatment and changes in laboratory parameters of each symptom score changes. Results: 1. Jianpihuoxuetongluo party group, the total effective rate (35%), adefovir dipivoxil group, the total effective rate (78.94%) and the combined treatment group, the total effective rate (80.96%) compared to group Jianpihuoxuetongluo side the efficacy of the latter two groups had significant difference (P <0.01); adefovir dipivoxil group and combined treatment group was not statistically significant (P> 0.05), which combined treatment group was the largest, indicating that the effect of combination therapy Best. (2) the three groups after treatment alanine aminotransferase (ALT), aspartate aminotransferase (AST) were significantly lower (P <0.05). In ALT, AST, the spleen and blood group and the other two parties had significant differences (P <0.01), adefovir dipivoxil group and the combined treatment group was not statistically significant (P> 0.05). Description JiangMei Jianpihuoxuetongluo side effects worse than adefovir, but the spleen and blood side and adefovir combination of both, can improve JiangMei results. 3 From ALT, AST before treatment, the treatment of the dynamic observation of 3,6 months, both gradually decreased with prolonged treatment, treatment for 6 months over 3 months of treatment. 4 6 months of treatment, the three groups of HBV-DNA quantification has declined compared with before treatment (P <0.01), described Jianpihuoxuetongluo parties and adefovir dipivoxil can inhibit viral replication; decline in HBV-DNA aspects , is superior to adefovir dipivoxil Jianpihuoxuetongluo side (P <0.05), combined viral load after Jianpihuoxuetongluo side down with adefovir dipivoxil alone showed no significant difference (P> 0.05). 5 after treatment with the three groups are part of the HBV-DNA negative, three groups, group Jianpihuoxuetongluo side HBV-DNA negative conversion rate than the other two groups had significant difference (P <0.01), while adefovir ester group of HBV-DNA negative rate compared with the combination group was not statistically significant (P> 0.05). In the negative side effects of Jianpihuoxuetongluo parties significantly less than adefovir. 6 After 6 months of treatment the symptom score three groups were decreased after treatment compared three groups of syndromes been improved (P <0.01). Fatigue, chest tightness, belching, hypochondriac pain, loose stools, loss of appetite and other symptoms, the treatment group after the three points was not statistically significant (P> 0.05). Jianpihuoxuetongluo party group and the combined treatment group patients in the mouth pain, bloating, irritability, nausea, vomiting and other aspects of the syndrome, compared with adefovir dipivoxil group had statistical significance. Description Jianpihuoxuetongluo parties alone and the combined use of adefovir dipivoxil in fatigue, chest tightness, belching, hypochondriac pain, loose stools, loss of appetite and other symptoms is superior to adefovir dipivoxil. Conclusion: Jianpihuoxuetongluo both parties and adefovir JiangMei, liver, improve clinical symptoms, inhibition of viral replication and so on, but in the improvement of clinical symptoms than Jianpihuoxuetongluo square adefovir dipivoxil, and in overall efficacy of combination therapy on the total efficiency of the largest party on the above aspects Jianpihuoxuetongluo combined with adefovir dipivoxil treatment of chronic hepatitis B e antigen-negative effect is most obvious.
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